1206625-70-8

Basic information

• Product Name: C₂₄H₂₅Cl₂F₃N₂O₅
• Synonyms: C₂₄H₂₅Cl₂F₃N₂O₅
• CAS NO: 1206625-70-8
• Molecular Weight: 549.374
• Mol File: 1206625-70-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₄H₂₅Cl₂F₃N₂O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₄H₂₅Cl₂F₃N₂O₅(1206625-70-8)
• EPA Substance Registry System: C₂₄H₂₅Cl₂F₃N₂O₅(1206625-70-8)

Safety Data

• Hazardous Substances Data: 1206625-70-8(Hazardous Substances Data)

Upstream product

• 2432-12-4 2,6-dichloro-4-methylophenol 
• 67848-59-3 4-piperidone-3-carboxylic acid ethyl ester 
• 106-44-5 p-cresol 
• 1206625-66-2 1-(2,2,2-trifluoro-acetyl)-4-trifluoromethanesulfonyloxy-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid ethyl ester 
• 1246643-49-1 C₁₀H₁₂F₃NO₄ 
• 1206625-60-6 2-[2-(2,6-dichloro-4-methyl-phenoxy)ethoxy]-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine 
• 945999-98-4 5-bromo-2-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]pyridine 

Downstream Products

• 1007392-69-9 MK-1597 
• 1206625-79-7 (3'R,4'S)-6-[2-(2,6-dichloro-4-methyl-phenoxy)ethoxy]-1',2',3',4',5',6'-hexahydro-[3,4']bipyridinyl-3'-carboxylic acid [2-chloro-5-(2-methoxy-ethyl)benzyl]cyclopropylamide acetate 
• 1265907-55-8 (3'S,4'S)-6-[2-(2,6-dichloro-4-methyl-phenoxy)ethoxy]-3',4',5',6'-tetrahydro-2'H-[3,4']bipyridinyl-1',3'-dicarboxylic acid 1'-tert-butyl ester 3'-ethyl ester 
• 1265907-56-9 C₂₇H₃₄Cl₂N₂O₆ 
• 1206625-73-1 (3'R,4'S)-3'-{[2-chloro-5-(2-methoxy-ethyl)-benzyl]cyclopropylcarbamoyl}-6-[2-(2,6-dichloro-4-methyl-phenoxy)ethoxy]-3',4',5',6'-tetrahydro-2'H-[3,4']bipyridinyl-1'-carboxylic acid tert-butyl ester 
• 1026786-82-2 (3'R,4'S)-6-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]-3',4',5',6'-tetrahydro-2'H-[3,4']bipyridinyl-1',3'-dicarboxylic acid 1'-tert-butyl ester 

Relevant articles and documents

A practical synthesis of renin inhibitor MK-1597 (ACT-178882) via catalytic enantioselective hydrogenation and epimerization of piperidine intermediate

A practical enantioselective synthesis of renin inhibitor MK-1597 (ACT-178882), a potential new treatment for hypertension, is described. The synthetic route provided MK-1597 in nine steps and 29% overall yield from commercially available p-cresol (7). The key features of this sequence include a catalytic asymmetric hydrogenation of a tetrasubstituted ene-ester, a highly efficient epimerization/saponification sequence of 4 which sets both stereocenters of the molecule, and a short synthesis of amine fragment 2.