120666-53-7Relevant academic research and scientific papers
Cinchona alkaloid ester derivatives as ligands in the asymmetric dihydroxylation and aminohydroxylation of alkenes
Chen, Hui,Wang, Qiao Feng,Sun, Xiao Li,Luo, Jing,Jiang, Ru
, p. 104 - 105 (2010)
Cinchona alkaloid ester derivatives were adopted to asymmetric dihydroxylation and asymmetric aminohydroxylation reactions in excellent yields and enantiomeric excesses.
Synthesis of N-vinyloxazolidinones and morpholines from amino alcohols and vinylsulfonium salts: Analysis of the outcome's dependence on the N-protecting group by nanospray mass spectrometry
Yar, Muhammad,Fritz, Sven P.,Gates, Paul J.,McGarrigle, Eoghan M.,Aggarwal, Varinder K.
supporting information; experimental part, p. 160 - 166 (2012/02/04)
The effect of the nature of the N-protecting group on 1,2-amino alcohols in annulation reactions with diphenylvinylsulfonium triflate has been investigated. Although tosyl and sulfinamide groups give morpholines in high yields, the use of N-Cbz leads to a high-yielding synthesis of N-vinyloxazolidinones. The reactions were monitored by nanospray MS/MS, which revealed why reactions are successful and the fate of reactive intermediates in the unsuccessful reactions.
ALKYLNITRILE QUINOLINES, AS NK-3 RECEPTOR LIGANDS
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Page/Page column 9; 13-14, (2008/06/13)
Compounds of Formula (I) wherein R 1 , A, 2 , R 3 , R 4 , R 5 , n, m and q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
Highly Enantioselective Synthesis of 1,2-Amino Alcohol Derivatives via Proline-Catalyzed Mannich Reaction
Pojarliev, Peter,Biller, William T.,Martin, Harry J.,List, Benjamin
, p. 1903 - 1905 (2007/10/03)
Here we report a new catalytic asymmetric synthesis of oxazolidin-2-ones 4 and Cbz-protected 1,2-amino alcohols 5. Our sequence is based on the chemistry of previously unknown 5-acyloxy-oxazolidin-2-ones, which are obtained via proline-catalyzed direct asymmetric three-component Mannich reaction and Baeyer-Villiger oxidation.
Spiroimidazolidine derivatives, their preparation, their use and pharmaceutical preparations formed therefrom
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, (2008/06/13)
The present invention relates to spiroimidazolidine derivatives of the formula I in which E, V, W, X, R1and R2have the meanings indicated in the claims. The compounds of the formula I are valuable pharmaceutical active compounds which are suitable, for example, for the therapy and prophylaxis of inflammatory disorders, such as, for example, rheumatoid arthritis, or allergic disorders. The compounds of the formula I are also inhibitors of the adhesion and migration of leukocytes and/or antagonists of the adhesion receptor VLA-4 belonging to the integrins group. They are generally suitable for the therapy and prophylaxis of illnesses which are caused by an undesired extent of leukocyte adhesion and/or leukocyte migration or are associated therewith or in which cell-cell or cell-matrix interactions which are based on interactions of VLA-4 receptors with their ligands play a part. The invention also relates to processes for the preparation of the compounds of the formula I, pharmaceutical preparations which contain compounds of the formula I, and methods for treating these disorders.
Salts of ethyl 3-(2-(4-(4-amino-imino-methyl)phenyl)-4-methyl-2,5-dioxo-imidazolidin-1-yl)acetylamino)-3-phenylpropionate
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, (2008/06/13)
The present invention relates to ethyl 3-(2-(4-(4-(amino-imino-methyl)-phenyl)-4-methyl-2,5-dioxoimidazolidin-1-yl)acetylamino)-3-phenylpropionate salts of the formula I, in which HM is maleic acid, and to their physiologically tolerated salts, thereof, to processes for their preparation and to their use in pharmaceuticals.
Substituted 5-membered ring heterocycles, their preparation and their use
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, (2008/06/13)
The present invention pertains to 5-ring heterocycles of general formula (I), wherein W, Y, Z, B, D, E and R as well as b, c, d, e, f, g, and h are as indicated in the description; to methods for preparing them, and to their use as inhibitors of platelet aggregation, metastasizing of carcinomatous cells and the attachment of osteoclasts to the bone surface. STR1
From styrenes to enantiopure α-arylglycines in two steps
Laxma Reddy,Barry Sharpless
, p. 1207 - 1217 (2007/10/03)
Direct enantioselective synthesis of (R)- and (S)-N-Cbz- or N- BOC-protected α-arylglycinols from styrenes via catalytic asymmetric aminohydroxylation, with enantioselective up to 99% and isolated yields up to 80%, is described. In a subsequent oxidation step, these glycinols yield the corresponding carbamate-protected α-arylglycines.
New synthesis of Evans chiral oxazolidinones by using Sharpless AA reaction
Li, Guigen,Lenington, Robert,Willis, Steven,Kim, Sun Hee
, p. 1753 - 1754 (2007/10/03)
Optically pure new Evans auxiliary analogs, (4R)- and (4S)-4-(2-naphthyl)oxazolidin-2-one, have been synthesized by using the Sharpless catalytic asymmetric aminohydroxylation reaction (Sharpless AA). The concise two-step synthesis involves a unique solution-to-solid Sharpless AA process and new neat cyclization conditions.
Erhoehung der Effizienz der katalytischen asymmetrischen Aminohydroxylierung durch N-Halogencarbamat-Salze
Li, Guigen,Angert, Hubert H.,Sharpless, K. Barry
, p. 2995 - 2999 (2007/10/03)
Keywords: Aminoalkohole; Asymmetrische Aminohydroxylierung; Carbamate; Katalyse
