130332-27-3 Usage
Uses
CI-988 is a potent and selective cholecystokinin 2 (CCK-2) receptor antagonist that displays ~ 1600-fold selectivity over CCK1 receptors and has negligible affinity at other binding sites. CI-988 exhibits anxiolytic activity following oral administration. CI-98 inhibited the proliferation of small cell lung cancer (SCLC) cells in mice.
Biological Activity
Potent and selective CCK 2 (CCK-B) receptor antagonist that displays ~ 1600-fold selectivity over CCK 1 receptors (IC 50 values are 1.7 and 2717 nM for CCK 2 and CCK 1 respectively). Has negligible affinity at a range of other binding sites (IC 50 > 10 μ M). Exhibits anxiolytic activity following oral administration.
Check Digit Verification of cas no
The CAS Registry Mumber 130332-27-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,0,3,3 and 2 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 130332-27:
(8*1)+(7*3)+(6*0)+(5*3)+(4*3)+(3*2)+(2*2)+(1*7)=73
73 % 10 = 3
So 130332-27-3 is a valid CAS Registry Number.
InChI:InChI=1/C35H42N4O6/c1-35(18-26-19-36-28-10-6-5-9-27(26)28,39-34(44)45-32-24-14-21-13-22(16-24)17-25(32)15-21)33(43)37-20-29(23-7-3-2-4-8-23)38-30(40)11-12-31(41)42/h2-10,19,21-22,24-25,29,32,36H,11-18,20H2,1H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)/t21?,22?,24?,25?,29-,32?,35+/m0/s1
130332-27-3Relevant articles and documents
Rationally Designed "Dipeptoid" Analogues of CCK. α-Methyltryptophan Derivatives as Highly Selective and Orally Active Gastrin and CCK-B Antagonists with Potent Anxiolytic Properties
Horwell, David C.,Hughes, John,Hunter, John C.,Pritchard, Martyn C.,Richardson, Reginald S.,at al.
, p. 404 - 414 (2007/10/02)
This paper describes the synthesis and structure-activity relationships (SAR) leading to the first rational design of "dipeptoid" analogues of the neuropeptide cholecystokinin (CCK).Compounds *,S*)>-4-2-3-(1H-indol-3-yl)-2-m