1207175-73-2 Usage
Uses
Used in Organic Synthesis:
Tert-butyl 5-bromo-3-hydroxypyridin-2-ylcarbamate serves as a key intermediate in the synthesis of complex organic molecules. Its presence of a bromine atom allows for a range of reactions, such as cross-coupling and substitution, facilitating the formation of new carbon-carbon or carbon-heteroatom bonds. The carbamate group can act as a protecting group for amines, enabling selective reactions and simplifying synthetic routes.
Used in Pharmaceutical Research:
In the pharmaceutical industry, tert-butyl 5-bromo-3-hydroxypyridin-2-ylcarbamate is utilized as a starting material for the development of new drugs. Its structural features can be exploited to design molecules with specific biological activities, such as antimicrobial, antiviral, or anticancer properties. tert-butyl 5-bromo-3-hydroxypyridin-2-ylcarbamate's reactivity and selectivity can be fine-tuned through the introduction of various functional groups, leading to the discovery of innovative therapeutic agents.
Used in Medicinal Chemistry:
Tert-butyl 5-bromo-3-hydroxypyridin-2-ylcarbamate plays a crucial role in medicinal chemistry, where it is employed to optimize the pharmacokinetic and pharmacodynamic properties of drug candidates. The tert-butyl group provides steric hindrance, influencing the compound's reactivity and selectivity in chemical reactions, while the carbamate group can be used to modulate the compound's lipophilicity and solubility. This allows researchers to fine-tune the drug's absorption, distribution, metabolism, and excretion, ultimately improving its therapeutic efficacy and safety profile.
Check Digit Verification of cas no
The CAS Registry Mumber 1207175-73-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,7,1,7 and 5 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1207175-73:
(9*1)+(8*2)+(7*0)+(6*7)+(5*1)+(4*7)+(3*5)+(2*7)+(1*3)=132
132 % 10 = 2
So 1207175-73-2 is a valid CAS Registry Number.
1207175-73-2Relevant academic research and scientific papers
PREPARATION METHOD FOR DEUTERATED MACROCYCLIC COMPOUND
-
Paragraph 0185-0186, (2022/02/05)
Provided are a compound as represented by formula (D) and a preparation method therefor, where X2 is a halogen, Pg is selected from H and an amino protecting group, such as Cbz, Boc, Fmoc, Alloc, Teoc, methoxycarbonyl or ethoxycarbonyl. Also pr
15-PGDH INHIBITOR
-
Paragraph 0347-0348, (2021/12/23)
[Problem] To provide a compound having a 15-PGDH inhibitory effect. [Solution] A compound represented by general formula (1) or a pharmacologically acceptable salt thereof.
Crizotinib Preparation Method
-
Paragraph 0038-0039, (2015/11/16)
The present invention relates to the technical field of medicine and organic synthesis, particularly to a method for preparing crizotinib. The method comprises the compound of formula b and the compound of formula e undergoing Suzuki coupling reaction to
A novel approach for the synthesis of Crizotinib through the key chiral alcohol intermediate by asymmetric hydrogenation using highly active Ir-Spiro-PAP catalyst
Qian, Jian-Qiang,Yan, Pu-Cha,Che, Da-Qing,Zhou, Qi-Lin,Li, Yuan-Qiang
, p. 1528 - 1531 (2014/03/21)
A novel approach for the synthesis of Crizotinib (1) is described. In addition, new efficient procedures have been developed for the preparation of (S)-1-(2,6-dichloro-3-fluorophenyl)ethanol (2) and tert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl) piperidine-1-carboxylate (4), the key intermediates required for the synthesis of Crizotinib.
