1207358-07-3Relevant articles and documents
Potent, selective, and orally bioavailable inhibitors of the mammalian target of rapamycin kinase domain exhibiting single agent antiproliferative activity
Koehler, Michael F. T.,Bergeron, Philippe,Blackwood, Elizabeth,Bowman, Krista K.,Chen, Yung-Hsiang,Deshmukh, Gauri,Ding, Xiao,Epler, Jennifer,Lau, Kevin,Lee, Leslie,Liu, Lichuan,Ly, Cuong,Malek, Shiva,Nonomiya, Jim,Oeh, Jason,Ortwine, Daniel F.,Sampath, Deepak,Sideris, Steve,Trinh, Lan,Truong, Tom,Wu, Jiansheng,Pei, Zhonghua,Lyssikatos, Joseph P.
, p. 10958 - 10971 (2013/02/25)
Selective inhibitors of mammalian target of rapamycin (mTOR) kinase based upon saturated heterocycles fused to a pyrimidine core were designed and synthesized. Each series produced compounds with Ki 500-fold sel
PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE
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Page/Page column 123, (2010/04/03)
Disclosed are compounds of Formula I, including steroisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, that are useful in modulating PIKK related kinase signaling, e.g., mTOR, and for the treatment of diseases (e.g., cancer) that are mediated at least in part by the dysregulation of the PIKK signaling pathway (e.g., mTOR).
