135481-57-1

Basic information

• Product Name: 6-BENZYL-5,6,7,8-TETRAHYDRO-1H-PYRIDO[4,3-D]PYRIMIDINE-2,4-DIONE
• Synonyms: 6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione;6-benzyl-1H,2H,3H,4H,5H,6H,7H,8H-pyrido[4,3-d]pyriMidine-2,4-dione;6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyriMidin-2,4(1H,3H)-dione;6-Benzyl-5,6,7,8-tetrahyd...;5,6,7,8-Tetrahydro-6-(phenylmethyl)pyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione;NSC 525977;6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H);6-BENZYL-5,6,7,8-TETRAHYDRO-1H-PYRIDO[4,3-D]PYRIMIDINE-2,4-DIONE
• CAS NO: 135481-57-1
• Molecular Formula: C₁₄H₁₅N₃O₂
• Molecular Weight: 257.29
• Mol File: 135481-57-1.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• Density: 1.33
• Refractive Index: 1.652
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 10.04±0.20(Predicted)
• CAS DataBase Reference: 6-BENZYL-5,6,7,8-TETRAHYDRO-1H-PYRIDO[4,3-D]PYRIMIDINE-2,4-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BENZYL-5,6,7,8-TETRAHYDRO-1H-PYRIDO[4,3-D]PYRIMIDINE-2,4-DIONE(135481-57-1)
• EPA Substance Registry System: 6-BENZYL-5,6,7,8-TETRAHYDRO-1H-PYRIDO[4,3-D]PYRIMIDINE-2,4-DIONE(135481-57-1)

Safety Data

• Hazardous Substances Data: 135481-57-1(Hazardous Substances Data)

Usage

General Description

6-Benzyl-5,6,7,8-tetrahydro-1H-pyrido[4,3-d]pyrimidine-2,4-dione is a chemical compound that falls under the category of tetrahydro-1H-Pyrido[4,3-d]pyrimidines. It has a complex molecular structure with benzyl groups. Its molecular formula is C14H14N2O2. While it is part of various chemical databases, specific details including its properties, uses, or involvement in any chemical reactions or biological processes, are not readily available or extensively researched in scientific literature. It's important to handle all chemicals with the appropriate safety measures.

InChI:InChI=1/C14H15N3O2/c18-13-11-9-17(8-10-4-2-1-3-5-10)7-6-12(11)15-14(19)16-13/h1-5H,6-9H2,(H2,15,16,18,19)

Upstream product

• 57-13-6 urea 
• 159660-85-2 1-benzyl-4-aminotetrahydropyridine-3-carboxylic acid methyl ester 
• 57611-47-9 1-benzyl-4-oxo-piperidine-3-carboxylic acid methyl ester 
• 1454-53-1 ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride 
• 782-87-6 N-benzylbis(2-cyanoethyl)amine 
• 111-94-4 3,3'-Iminodipropionitrile 
• 67140-12-9 6-benzyl-2-thioxo-2,3,5,6,7,8-hexahydro-1H-pyrido<4,3-d>pyrimidin-4-one 
• 135481-54-8 4-ethoxy-5,6,7,8-tetrahydro-6-(phenylmethyl)-pyrido<4,3-d>pyrimidin-2(1H)-one 
• 41276-30-6 C₉H₁₄O₃NC₆H₅ 
• 14247-04-2 4-amino-1-benzyl-1.2.5.6-tetrahydropyridine-3-carbonitrile 
• 100-39-0 benzyl bromide 

Downstream Products

• 635698-66-7 6-Benzyl-2,4-dibromo-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine 
• 1207358-07-3 C₂₅H₃₄N₆O₄ 
• 1207358-19-7 C₂₄H₂₈N₈O₂ 
• 1208901-69-2 2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride 
• 1207358-03-9 C₂₀H₂₆N₆O₂ 
• 1207358-49-3 C₂₆H₃₆N₆O₄ 
• 1207358-51-7 C₂₁H₂₈N₆O₂ 
• 1201781-22-7 2,4-dichloro-6-(1-chloroethoxycarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine 

Relevant articles and documents

NOVEL TETRAHYDROPYRIDOPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION

The present invention provides novel compounds having the general formula: wherein R1, R2 and R3 are as described herein, compositions including the compounds and methods of using the compounds.

GLYCOSIDASE INHIBITORS

Compounds of formula (I) wherein A, R, W, Q, n and m have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.

FUSED PYRIMIDINES AS INHIBITORS OF p97 COMPLEX

Fused pyrimidine compounds having a saturated, unsaturated or aromatic A ring fused to a pyrimidine ring and having a complex substituents at the 2 position and a substituted amine at the 4 position of the pyrimidine ring as well as optional aliphatic, functional and/or aromatic components substituted at other positions of the pyrimidine ring and A ring are disclosed. These compounds are inhibitors of the AAA proteasome complex containing p97 and are effective medicinal agents for treatment of diseases associated with p97 bioactivity such as cancer.