1207454-57-6

Basic information

• Product Name: ethyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1H-1,2,4-triazol-5-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate
• Synonyms: ethyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1H-1,2,4-triazol-5-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate
• CAS NO: 1207454-57-6
• Molecular Weight: 412.396
• Mol File: 1207454-57-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ethyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1H-1,2,4-triazol-5-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1H-1,2,4-triazol-5-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate(1207454-57-6)
• EPA Substance Registry System: ethyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1H-1,2,4-triazol-5-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate(1207454-57-6)

Safety Data

• Hazardous Substances Data: 1207454-57-6(Hazardous Substances Data)

Upstream product

• 1207453-95-9 (E)-6-fluoro-4-(4-fluorobenzylideneamino)isobenzofuran-1(3H)-one 
• 141-52-6 sodium ethanolate 
• 99651-37-3 2-methyl-2H-1,2,4-triazole-3-carbaldehyde 
• 105-37-3 Ethyl propionate 
• 33184-16-6 5-fluoro-2-methylbenzoic acid 
• 697739-03-0 5-fluoro-2-methyl-3-nitrobenzoic acid methyl ester 
• 850462-64-5 5-fluoro-2-methyl-3-nitrobenzoic acid 
• 850462-65-6 2-bromomethyl-5-fluoro-3-nitrobenzoic acid methyl ester 
• 1207453-90-4 6-fluoro-4-nitroisobenzofuran-1(3H)-one 
• 1207453-91-5 4-amino-6-fluoroisobenzofuran-1(3H)-one 
• 64-17-5 ethanol 

Downstream Products

• 1207456-01-6 ((11S,12R)-7-fluoro-11-(4-fluorophenyl)-12-(2-methyl-1,2,4-triazol-3-yl)-2,3,10-triazatricyclo[7.3.1.05,13]trideca-1,5⁽¹³⁾,6,8-tetraen-4-one) 
• 1207456-00-5 (8R,9S)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3 ,2-de] phthalazin-3(7H)-one 
• 1207454-56-5 5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one 

Relevant articles and documents

DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY (ADP-RIBOSE) POLYMERASE (PARP) FOR THE TREATMENT OF MULTIPLE MYELOMA

Provided is a methods of treating multiple myeloma with inhibitors of poly(ADP-ribose)polymerase according to Formula (I):

DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)

A compound having the structure set forth in Formula (I) and Formula (II): wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.