ethyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1H-1,2,4-triazol-5-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate

Base Information

• Chemical Name: ethyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1H-1,2,4-triazol-5-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate
• CAS No.: 1207454-57-6
• Molecular Formula: C₂₁H₁₈F₂N₄O₃
• Molecular Weight: 412.396

Synonyms:ethyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1H-1,2,4-triazol-5-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate

Chemical Property of ethyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1H-1,2,4-triazol-5-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate

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Technology Process of ethyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1H-1,2,4-triazol-5-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate

There total 9 articles about ethyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1H-1,2,4-triazol-5-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

(E)-6-fluoro-4-(4-fluorobenzylideneamino)isobenzofuran-1(3H)-one (1207453-95-9) + sodium ethanolate (141-52-6) + 2-methyl-2H-1,2,4-triazole-3-carbaldehyde (99651-37-3) → ethyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1H-1,2,4-triazol-5-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate (1207454-57-6)

Guidance literature:

In ethanol; Ethyl propionate; at 37 - 40 ℃;

Reference yield: 14.0%

(E)-6-fluoro-4-(4-fluorobenzylideneamino)isobenzofuran-1(3H)-one (1207453-95-9) + sodium ethanolate (141-52-6) + Ethyl propionate (105-37-3,20741-13-3) + 2-methyl-2H-1,2,4-triazole-3-carbaldehyde (99651-37-3) → ethyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1H-1,2,4-triazol-5-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate (1207454-57-6)

Guidance literature:

In ethanol; at 37 - 40 ℃; for 6h;

Reference yield: 14.0%

ethanol (64-17-5) + (E)-6-fluoro-4-(4-fluorobenzylideneamino)isobenzofuran-1(3H)-one (1207453-95-9) + sodium ethanolate (141-52-6) + 2-methyl-2H-1,2,4-triazole-3-carbaldehyde (99651-37-3) → ethyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1H-1,2,4-triazol-5-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate (1207454-57-6)

Guidance literature:

at 40 ℃; for 6h;

upstream raw materials:

(E)-6-fluoro-4-(4-fluorobenzylideneamino)isobenzofuran-1(3H)-one

sodium ethanolate

2-methyl-2H-1,2,4-triazole-3-carbaldehyde

Ethyl propionate

Downstream raw materials:

5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

((11S,12R)-7-fluoro-11-(4-fluorophenyl)-12-(2-methyl-1,2,4-triazol-3-yl)-2,3,10-triazatricyclo[7.3.1.05,13]trideca-1,5⁽¹³⁾,6,8-tetraen-4-one)

(8R,9S)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3 ,2-de] phthalazin-3(7H)-one

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