99591-85-2

Basic information

• Product Name: 6-<4-(N'-cyano-S-methylisothioureido)phenyl>-5-methyl-4,5-dihydropyridazin-3(2H)-one
• CAS NO: 99591-85-2
• Molecular Weight: 301.372
• Mol File: 99591-85-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-<4-(N'-cyano-S-methylisothioureido)phenyl>-5-methyl-4,5-dihydropyridazin-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-<4-(N'-cyano-S-methylisothioureido)phenyl>-5-methyl-4,5-dihydropyridazin-3(2H)-one(99591-85-2)
• EPA Substance Registry System: 6-<4-(N'-cyano-S-methylisothioureido)phenyl>-5-methyl-4,5-dihydropyridazin-3(2H)-one(99591-85-2)

Safety Data

• Hazardous Substances Data: 99591-85-2(Hazardous Substances Data)

Upstream product

• 36725-27-6 SKF 93741 
• 103-84-4 Acetanilid 
• 120757-13-3 4-(4-aminophenyl)-3-methyl-4-oxobutanoic acid hydrochloride 
• 120757-14-4 3-(4-acetamidobenzoyl)-4-(N-piperidinyl)butanoic acid 
• 81937-39-5 2-ethoxycarbonyl-3-(4-acetamidobenzoyl)butyric acid ethyl ester 
• 120757-15-5 4-(4-Amino-phenyl)-4-oxo-3-piperidin-1-ylmethyl-butyric acid methyl ester 
• 120757-17-7 methyl 3-(4-acetaminobenzoyl)butyrate 
• 120757-16-6 3-(4-Acetylamino-benzoyl)-but-3-enoic acid methyl ester 
• 81112-08-5 N-[4-(2-chloro-1-oxopropyl)phenyl]acetamide 
• 5473-15-4 4-(4-acetamidophenyl)-4-oxobutanoic acid 
• 10191-60-3 dimethyl N-cyanodithioiminocarbonate 
• 36725-28-7 6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone 

Downstream Products

• 115344-47-3 2 cyano 1 methyl 3 [4 (4 methyl 6 oxo 1,4,5,6 tetrahydro 3 pyridazinyl)phenyl]guanidine 

Relevant articles and documents

6-(substituted phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-ones of medicinal interest. The synthesis of SK&F 94836 and SK&F 95654

Two synthetic routes to the dihydropyridazinone-cyanoguanidine 4 (SK&F 94836) are described, both proceeding via the anilino compound 6. An efficient synthesis of the dihydropyridazinone-pyridone 5 (SK&F 95654) is reported. This synthesis proceeds via the fluoro-keto-acid 24, with subsequent displacement of the fluoro substituent by 4-pyridone. The surprising effectiveness of water as a solvent in this reaction has been highlighted.