120759-99-1

Basic information

• Product Name: (E)-6-phenyl-4-oxo-5-hexenal
• Synonyms: (E)-6-phenyl-4-oxo-5-hexenal
• CAS NO: 120759-99-1
• Molecular Weight: 188.226
• Mol File: 120759-99-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (E)-6-phenyl-4-oxo-5-hexenal(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-6-phenyl-4-oxo-5-hexenal(120759-99-1)
• EPA Substance Registry System: (E)-6-phenyl-4-oxo-5-hexenal(120759-99-1)

Safety Data

• Hazardous Substances Data: 120759-99-1(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 86197-12-8 dimethyl <4-(1,3-dioxolan-2-yl)-2-oxobutyl>phosphonate 
• 120760-01-2 (E)-2-(3-oxo-5-phenyl-4-pentenyl)-1,3-dioxolane 

Downstream Products

• 131570-72-4 (3R,4aR,7aR,8S,8aS)-3,8-Diphenyl-hexahydro-cyclopenta[4,5]pyrrolo[1,2-c]thiazol-7-one 
• 131570-73-5 (1R,3R,6S,7S,11S)-3,11-Diphenyl-4-thia-2-aza-tricyclo[5.3.1.0^2,6]undecan-8-one 
• 131570-68-8 (3R,3aS,6aS)-1-Methyl-3-phenyl-hexahydro-cyclopenta[b]pyrrol-4-one 
• 131570-69-9 (1S,5R,8R)-6-Methyl-8-phenyl-6-aza-bicyclo[3.2.1]octan-2-one 
• 131570-70-2 (4aS,7aS,8R,8aR)-8-Phenyl-hexahydro-cyclopenta[4,5]pyrrolo[1,2-c]thiazol-7-one 
• 131570-71-3 (1S,6R,7R,11R)-11-Phenyl-4-thia-2-aza-tricyclo[5.3.1.0^2,6]undecan-8-one 

Relevant articles and documents

Synthesis of (E)-4-oxo-5-hexenals and their acetal derivatives

An effective synthesis of (E)-4-oxo-5-hexenals 6 and the acetals 5 starting from ethyl 2-alkoxy-1-cyclopropanecarboxylates 1a-d is presented. The acid-induced ring opening of the cyclopropanecarboxylates 1a, b followed by phosphorylmethylation or the phosphorylmethylation of the ester 1c followed by ring opening leads to the 5-acetal of 2,5-dioxopentylphosphonate 4. The Horner-Emmons olefination of 4 with various aldehydes produces the title compounds.