120760-01-2Relevant academic research and scientific papers
Synthesis of (E)-4-oxo-5-hexenals and their acetal derivatives
Kanemasa,Otsuka,Doi,Tsuge,Wada
, p. 1167 - 1169 (2007/10/02)
An effective synthesis of (E)-4-oxo-5-hexenals 6 and the acetals 5 starting from ethyl 2-alkoxy-1-cyclopropanecarboxylates 1a-d is presented. The acid-induced ring opening of the cyclopropanecarboxylates 1a, b followed by phosphorylmethylation or the phosphorylmethylation of the ester 1c followed by ring opening leads to the 5-acetal of 2,5-dioxopentylphosphonate 4. The Horner-Emmons olefination of 4 with various aldehydes produces the title compounds.
Synthesis and Acid-Catalyzed Ring Opening of 1-Alkenyl Cyclopropyl Ketones
Tsuge, Otohiko,Kanemasa, Shuji,Otsuka, Tatsuya,Suzuki, Toshiro
, p. 2897 - 2908 (2007/10/02)
1-Alkenyl cyclopropyl ketones, when activated by cation-stabilizing substituents at the ring carbon or at the terminal carbon of the enone moiety, undergo polyphosphoric acid-catalyzed ring enlargement producing cyclopentanone or cyclohexenone derivatives
