120779-90-0

Upstream product

• 121194-19-2 N-tert-Butyl-N-methyl-N'-[2-phenyl-eth-(E)-ylidene]-hydrazine 
• 407-25-0 trifluoroacetic anhydride 
• 122-78-1 phenylacetaldehyde 

Downstream Products

• 121194-37-4 4,4,4-Trifluoro-1-phenyl-butan-2-one 
• 121194-38-5 4,4,4-trifluoro-3-hydroxy-1-phenylbutan-2-one 
• 120779-95-5 1-(tert-Butyl)-3-benzyl-4-trifluoromethylpyrazole 
• 121194-32-9 ((E)-1-Benzyl-3,3,3-trifluoro-propenyl)-tert-butyl-diazene 
• 129206-93-5 5-Benzyl-3-tert-butyl-6-trifluoromethyl-3,6-dihydro-2H-[1,3,4]oxadiazine 
• 129247-53-6 1-(t-Butyl)-4-benzyl-5-trifluoromethylimidazole 

Relevant academic research and scientific papers

4- and 5-Trifluoromethylimidazoles. Novel Cyclization of Trifluoroacetylated Aldehyde Dimethylhydrazones

Thermally induced cyclization reaction of trifluoroacetylated arylaldehyde dimethylhydrazones 1 in refluxing toluene afforded 1-methyl-4-aryl-5-trifluoromethylimidazoles 2 in good yields.In contrast thermal cyclization of 1 in the presence of silica gel gave regioisomeric 1-methyl-4-trifluoromethyl-5-aryl-imidazoles 5 as major products.These reactions could be extended to the synthesis of related several 1,4,5-trisubstituted imidazoles.

Convenient Synthesis of 1,1,1-trifluoro-4,5-diaza-2,4-alkadienes and 1-Aryl-3,3,3-trifluoro-1-propanones

Several 3-aryl-1,1,1-trifluoro-4,5-diaza-2,4-alkadienes 3 were synthesized in good yields from arenecarbaldehyde dimethylhydrazones 1 or its trifluoroacetylated derivatives 2 by reaction with an excess of trifluoroacetic anhydride in pyridine.Acid hydroly