121194-38-5

Upstream product

• 121194-32-9 ((E)-1-Benzyl-3,3,3-trifluoro-propenyl)-tert-butyl-diazene 
• 407-25-0 trifluoroacetic anhydride 
• 828-01-3 phenyllactic acid 
• 80768-54-3 (+/-)-E-1,1,1-trifluoro-4-phenylbut-3-en-2-ol 
• 106942-38-5 4-Benzyl-2-phenyl-4-(2,2,2-trifluoro-acetyl)-4H-oxazol-5-one 
• 5874-61-3 4-benzyl-2-phenyl-2-oxazolin-5-one 
• 121194-19-2 N-tert-Butyl-N-methyl-N'-[2-phenyl-eth-(E)-ylidene]-hydrazine 
• 120779-90-0 3-(tert-Butyl-methyl-hydrazono)-1,1,1-trifluoro-4-phenyl-butan-2-one 
• 78348-48-8 N-benzoyl-N-methylphenylalanine 
• 106745-98-6 (3RS)-2-oxo-4-phenyl-3-(phenylcarbonyl)amino-1,1,1-trifluorobutane 

Relevant academic research and scientific papers

Oxidation of fluoroalkyl-substituted allylic alcohols: A synthesis of fluorinated α,β-epoxyketones

Fluoroalkyl-substituted allylic alcohols are readily and selectively oxidized at the hydroxyl group with the Swern or Dess-Martin reagents to give α,β-unsaturated ketones, and on treatment with m-chloroperbenzoic acid or tert-butyl hydroperoxide they are oxidized to the corresponding epoxyalcohols. The latter are oxidized by Swern or Dess-Martin reagents at the hydroxyl group to α,β-epoxyketones, which form hydrates stable under the conditions of isolation.

A Convenient Synthesis of α-Trifluoromethylated and α-Perfluoroalkylated Acyloins from α-Hydroxy Acids

A novel transformation of α-hydroxy acids to α-trifluoromethylated and α-perfluoroalkylated acyloins was efficiently realized by utilizing trifluoroacetic or perfluoroalkylcarboxylic anhydrides in the presence of pyridine, in which probable intermediates were meso-ionic 1,3-dioxolium-4-olates.

Convenient synthesis of α-trifluoromethylated acyloins from α-hydroxy or α-amino acids

α-Trifluoromethylated acyloins (2 and 6) have been prepared from α-hydroxy acids (1), N-acylprolines (5) or N-acyl-N-alkyl α-amino acids (8) by novel transformation reactions with trifluoroacetic anhydride (TFAA) in the presence of pyridine. The former reaction of 1 could proceed through mesoionic 1,3-dioxolium-4-olates, whereas the latter two reactions of α-amino acids (5 and 8) could involve mesoionic 1,3-oxazolium-5-olates. The reaction of 1 with TFAA shows more potential for practical applications because of the ready availability of the starting materials and ease of manipulation.

Unusual reactions of secondary amino acids with trifluoroacetic anhydride: A novel access to α-trifluoromethylated acyloins

A new fragmentation reaction of secondary α-amino acids with trifluoroacetic anhydride under Dakin-West reaction conditions proceeds through oxazolium salt intermediates followed by ring cleavage to form α- trifluoromethylated acyloins in good yields.

Synthesis of peptidyl fluoromethyl ketones and peptidyl α-keto esters as inhibitors of porcine pancreatic elastase, human neutrophil elastase, and rat and human neutrophil cathepsin G

Comparison of MeO-Suc-Val-Pro-Phe-CO2Me (29) and MeO-Suc-Ala-Ala-Pro-Phe-CO2Me (25) with their corresponding trifluoromethyl ketones 9a and 9b, respectively, in rat and human neutrophil cathepsin G assays showed the α-keto esters to

Convenient Synthesis of 1,1,1-trifluoro-4,5-diaza-2,4-alkadienes and 1-Aryl-3,3,3-trifluoro-1-propanones

Several 3-aryl-1,1,1-trifluoro-4,5-diaza-2,4-alkadienes 3 were synthesized in good yields from arenecarbaldehyde dimethylhydrazones 1 or its trifluoroacetylated derivatives 2 by reaction with an excess of trifluoroacetic anhydride in pyridine.Acid hydroly