121194-19-2

Upstream product

• 7400-27-3 tertbutylhydrazine hydrochloride 
• 122-78-1 phenylacetaldehyde 
• 74-88-4 methyl iodide 

Downstream Products

• 129247-53-6 1-(t-Butyl)-4-benzyl-5-trifluoromethylimidazole 
• 120779-90-0 3-(tert-Butyl-methyl-hydrazono)-1,1,1-trifluoro-4-phenyl-butan-2-one 
• 121194-38-5 4,4,4-trifluoro-3-hydroxy-1-phenylbutan-2-one 
• 121194-37-4 4,4,4-Trifluoro-1-phenyl-butan-2-one 
• 121194-32-9 ((E)-1-Benzyl-3,3,3-trifluoro-propenyl)-tert-butyl-diazene 
• 120779-95-5 1-(tert-Butyl)-3-benzyl-4-trifluoromethylpyrazole 

Relevant academic research and scientific papers

4- and 5-Trifluoromethylimidazoles. Novel Cyclization of Trifluoroacetylated Aldehyde Dimethylhydrazones

Thermally induced cyclization reaction of trifluoroacetylated arylaldehyde dimethylhydrazones 1 in refluxing toluene afforded 1-methyl-4-aryl-5-trifluoromethylimidazoles 2 in good yields.In contrast thermal cyclization of 1 in the presence of silica gel gave regioisomeric 1-methyl-4-trifluoromethyl-5-aryl-imidazoles 5 as major products.These reactions could be extended to the synthesis of related several 1,4,5-trisubstituted imidazoles.