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120786-18-7 Usage


Huperzine A is an alkaloid extract derived from the Chinese club moss Huperzia serrata. It is an acetylcholinesterase inhibitor, which helps promote higher levels of acetylcholine in the brain. Higher levels of acetylcholine support one's ability to perform cognitive tasks such as learning new things, memorizing information, and focusing at the task at hand. Huperzine A is considered to be a nootropic supplement because it supports cognitive function. It is considered a focus and memory nootropic similar to alpha gpc, bacopa, phosphatidylcholine, cdp choline, sulbutiamine, and uridine. It is also considered a brain booster as it is used for brain health and support. Huperzine A for many years has been widely used in traditional Chinese medicine to enhance memory and to treat fever and inflammation. In the United States, it is commercially available as a food supplement, but has not been approved by the FDA as a treatment for AD or other cognitive disorders.


Used in Pharmaceutical Industry:
Huperzine A is used as a dementia treatment for Alzheimer's disease and as a muscle strength enhancer for myasthenia gravis. It is an NMDA antagonist, which helps improve cognitive function and memory.
Used in Research Applications:
Huperzine A has been used in anti-acetylcholinesterase bioautographic assay, which is a method for detecting the presence of acetylcholinesterase inhibitors. This application helps in the development of new drugs and therapies for cognitive disorders and other related conditions.
Note: Huperzine A is a synthetic compound, and its occurrence is not mentioned in the provided materials.


Huperzine A can help support learning and memory by protecting acetylcholine, a neurotransmitter that acts as a messenger molecule in the brain. Huperzine A may be used for both short-term "brain boost" needs, such as preparing for a test, as well as more long-term needs, such as reducing the mild memory loss associated with normal aging.ACETYLCHOLINESTERASE INHIBITOR - Huperzine A acts as a reversible Acetylcholinesterase inhibitor meaning it supports levels of the neurotransmitter acetylcholine which plays a key role in cognitive function.SUPPORTS COGNITIVE FUNCTION - Supports working memory, motivation, and problem solving ability.SUPPORTS ENERGY AND STAMINA - Huperzine A supports mental energy, stamina, and sustained focus.

Biological Activity

Huperzine A is an effective acetylcholinesterase inhibitor and can cross the blood-brain barrier. Huperzine A is known to prevent cognitive defects, glutamate-induced nerve cell death.It is recognized for its use in the treatment of Alzheimer′s disease and organophosphate poisoning.

Side effects

When taken at recommended doses Huperzine A is well tolerated and presents few side effects. Rarely, side effects including nausea, diarrhea, and loss of appetite may occur. Adverse side effects are more likely when exceeding the recommended dosage.Huperzine A is not recommended for people suffering from heart conditions, consult your physician before taking this product.

Dosage forms

Huperzine A supplementation tends to be in the range of 50 - 200 mcg daily. Our tablets are 200 mcg each, but can be easily broken into halves or quarters for those wishing to take smaller doses.Huperzine A has a long half-life (10-14 hours), so cycling this product is often recommended. We recommend taking it no more than 2-3 times per week, or if using it daily we recommend taking a 1 week break for every 2 weeks of use.

Check Digit Verification of cas no

The CAS Registry Mumber 120786-18-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,7,8 and 6 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 120786-18:
117 % 10 = 7
So 120786-18-7 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017


1.1 GHS Product identifier

Product name (5R,9R,11E)-5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one

1.2 Other means of identification

Product number -
Other names (+/-)-Huperazine A

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:120786-18-7 SDS

120786-18-7Upstream product

120786-18-7Relevant articles and documents

Synthetic method of huperzine A


Paragraph 0075; 0077; 0118-0121, (2019/05/15)

The invention belongs to the technical field of medicine synthesis and particularly relates to a synthetic method of huperzine A. The method includes twelve steps of reactions, 1,4-dioxaspiro[4.5]decan-8-one being a raw material, so that the chemical synthesis of the huperzine A is completed at a high total yield. The method is fewer in reaction steps, is simple in operations, has high yield, is stable in intermediates and gentle in reaction conditions, and is easy to control in reactions.



Page/Page column 10, (2016/04/26)

A method of resolving a racemic mixture of (±) Huperzine A to (-)-Huperzine A includes: separating the (-)-Huperzine A from the racemic mixture of (±) Huperzine A by chiral high performance liquid chromatography (HPLC), the chiral HPLC being performed utilizing a mobile phase including a solution including an alcohol and one selected from dichloromethane, trichloromethane, and a mixture thereof, and the chiral HPLC being performed utilizing a chiral stationary phase including a polysaccharide derivative.

An efficient total synthesis of (-)-huperzine A

Ding, Rui,Sun, Bing-Feng,Lin, Guo-Qiang

supporting information, p. 4446 - 4449 (2012/10/29)

The total synthesis of Lycopodium alkaloid (-)-huperzine A has been accomplished in 10 steps with 17% overall yield from commercially abundant (R)-pulegone. The synthetic route features an efficient synthesis of 4 via a Buchwald-Hartwig coupling reaction,

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