123435-97-2

Basic information

• Product Name: 5,6,7,8-tetrahydro-2-methoxy-6-oxo-5-quinolinecarboxylic acid methyl ester
• CAS NO: 123435-97-2
• Molecular Weight: 235.24
• Mol File: 123435-97-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 5,6,7,8-tetrahydro-2-methoxy-6-oxo-5-quinolinecarboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6,7,8-tetrahydro-2-methoxy-6-oxo-5-quinolinecarboxylic acid methyl ester(123435-97-2)
• EPA Substance Registry System: 5,6,7,8-tetrahydro-2-methoxy-6-oxo-5-quinolinecarboxylic acid methyl ester(123435-97-2)

Safety Data

• Hazardous Substances Data: 123435-97-2(Hazardous Substances Data)

Upstream product

• 120686-09-1 2-methoxy-6-oxo-5,6,7,8-tetrahydroquinoline 
• 616-38-6 carbonic acid dimethyl ester 
• 120685-98-5 1',5',7',8'-tetrahydro-1'-(phenylmethyl)spiro<1,3-dioxolane-2,6'(2'H)-quinolin>-2'-one 
• 57440-57-0 1-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)pyrrolidine 
• 186958-45-2 3-(3-Carboxymethyl-6-methoxy-pyridin-2-yl)-propionic acid methyl ester 
• 186958-44-1 6-(3-butenyl)-2-methoxy-5-(2-propenyl)pyridine 
• 1026427-81-5 3-(3-carboxymethyl-6-methoxy-pyridin-2-yl)-propionic acid 
• 283612-40-8 2-methoxy-5-(3-methyl-2-butenyl)-6-(4-methyl-3-pentenyl)-pyridine 
• 283612-39-5 5-bromo-2-methoxy-6-(4-methyl-3-pentenyl)pyridine 
• 126717-59-7 3-bromo-6-methoxy-2-methylpyridine 
• 63071-03-4 2-methoxy-6-methyl-pyridine 
• 3279-76-3 6-hydroxy-2-methylpyridine 
• 120686-08-0 1',5',7',8'-tetrahydrospiro<1,3-dioxolane-2,6'(2'H)-quinolin>-2'-one 
• 120685-99-6 7',8'-dihydro-2'-methoxyspiro<1,3-dioxolane-2,6'(5'H)-quinoline> 

Downstream Products

• 258522-24-6 5,6,7,8-tetrahydro-2-methoxy-6-oxo-5-quinolinecarboxylic acid, (1R,2S)-2-phenylcyclohexyl ester 
• 258522-25-7 (5S)-7,8,9,10-tetrahydro-2-methoxy-7-methylene-11-oxo-5,9-methanocycloocta[b]pyridine-5(6H)carboxylic acid, (1R,2S)-2-phenylcyclohexyl ester 
• 258522-26-8 (1S,9R)-5-Methoxy-11,13-dimethylene-6-aza-tricyclo[7.3.1.0^2,7]trideca-2,4,6-triene-1-carboxylic acid (1R,2S)-2-phenyl-cyclohexyl ester 
• 283612-41-9 (Z)-(5S)-11-ethylidene-7,8,9,10-tetrahydro-2-methoxy-7-methylene-5,9-methanocycloocta[b]pyridine-5(6H)carboxylic acid, (1R,2S)-2-phenylcyclohexyl ester 
• 116-28-9 (-)-huperzine A 
• 92138-20-0 1-amino-13-ethylidene-11-methyl-6-aza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,10-trien-5-one 
• 120786-18-7 (+/-)-huperzine 

Relevant articles and documents

New straightforward route to an Huperzine A synthetic intermediate

A five step sequence of reactions afforded in high yield the tetrahydroquinoline derivative 3, a key intermediate in Huperzine A synthesis.

Development of a large-scale synthetic route to manufacture (-)-huperzine A

A safe, practical and scalable process for manufacture of (-)-huperzine A has been developed and scaled up to manufacture several hundred grams of (-)-huperzine A with chemical and optical purity of >99%. The process consists of 11 chemical stages starting from commercially available materials with only nine isolation steps and no chromatography purification. This process provides a reliable and cost-effective source of synthetic (-)-huperzine A and its derivatives for pharmaceutical and nutraceutical markets.

Racemic huperzine A

The present invention relates to racemic huperzine A, a pharmaceutical composition comprising huperzine A, its use as a medicament and for the manufacture of a medicament for the inhibition of the cholesterase enzymes in a mammal.