120791-81-3

Upstream product

• 15761-38-3 L-N-Boc-Ala 
• 16652-71-4 benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride 
• 541-41-3 chloroformic acid ethyl ester 
• 147-85-3 L-proline 
• 100-51-6 benzyl alcohol 
• 16357-59-8 N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline 

Relevant academic research and scientific papers

Convenient method for the synthesis of N-(ethyloxycarbonyl) ester derivatives from amino acids

Amino acids upon treatment with ethyl chloroformate in methanol in the presence of potassium carbonate give the corresponding N-(ethyloxycarbonyl) amino acid ester derivatives in good yields. These derivatives can be also synthesized by performing the reaction in THF in the presence of alcohols.

Synthesis of O-Glycopeptides of the N-Terminus of Interleukin-2

The synthesis of a number of O-glycopeptides with different lengths of chain of between 3 and 10 amino acids that are part of the N-terminus of interleukin-2 is described.The key intermediate for the syntheses is O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-galactopyranosyl)-N-(9-fluorenylmethoxycarbonyl)-L-threonine tert-butyl ester (9b), to which suitably protected amino acids and peptides can be added C- or N-terminally. 9b is an element, which allows to insert glycosylated hydroxyamino acids with the Fmoc/tBu combination of protective groups, which are approved in peptide synthesis.During the syntheses peptide blocks are used.With the deprotected products it is possible to test the structural specificity of glycosyl transferases.