324784-93-2Relevant academic research and scientific papers
An elusive thermal [2 + 2] cycloaddition driven by visible light photocatalysis: Tapping into strain to access C 2-symmetric tricyclic rings
Singh, Kamaljeet,Trinh, Winston,Weaver, Jimmie D.
, p. 1854 - 1861 (2019/02/20)
A mild and operationally simple methodology is reported for the synthesis of cyclobutane rings imbedded within a C2-symmetric tricyclic framework. The method uses visible light and an iridium-based photocatalyst to drive the oft-stated "forbidden" thermal
Antibacterial homopiperidinyl substituted 3,4 dihydro 1H[1,8]naphthyridinones
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, (2014/06/25)
The present invention is related to novel compounds of formula (I) that inhibit the activity of the FabI enzyme which are therefore useful in the treatment of bacterial infections. It further relates to pharmaceutical compositions comprising these compounds, and chemical processes for preparing these compounds.
NEW ANTIBACTERIAL COMPOUNDS
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, (2014/03/21)
The present invention is related to novel compounds of formula (I) that may inhibit the activity of the FabI enzyme, and which are useful in the treatment of bacterial infections. It further relates to pharmaceutical compositions comprising these compound
ANTIBACTERIAL HOMOPIPERIDINYL SUBSTITUTED 3,4 DIHYDRO 1H [1,8]NAPHTHYRIDINONES
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, (2013/03/26)
The present invention is related to novel compounds of formula (I) that inhibit the activity of the FabI enzyme which are therefore useful in the treatment of bacterial infections. It further relates to pharmaceutical compositions comprising these compounds, and chemical processes for preparing these compounds.
SUBSTITUTED AZEPINE- AND DIAZEPINE-SULFONAMIDES USEFUL TO INHIBIT 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1
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Page/Page column 57, (2009/04/25)
In its many embodiments, the present invention relates to a novel class of substituted azepine- and diazepine-sulfonamide compounds useful to inhibit 11BETA-hydroxysteroid dehydrogenase type-1, pharmaceutical compositions containing the compounds, and met
The discovery of azepane sulfonamides as potent 11β-HSD1 inhibitors
Neelamkavil, Santhosh F.,Boyle, Craig D.,Chackalamannil, Samuel,Greenlee, William J.,Zhang, Lili,Terracina, Giuseppe
scheme or table, p. 4563 - 4565 (2010/04/05)
Discovery of a series of azepine sulfonamides as potent inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is described. SAR studies at the 4-position of the azepane ring have resulted in the discovery of a very potent compound 30 which has
