1164-14-3

Upstream product

• 1619972-69-8 C₁₉H₂₄N₂O₄ 
• 1619972-80-3 C₉H₁₆O₃ 
• 1619972-60-9 C₁₆H₂₇NO₇ 
• 1619972-56-3 C₁₇H₂₉NO₆ 
• 64-17-5 ethanol 
• 100-46-9 benzylamine 
• 140-88-5 ethyl acrylate 
• 7425-53-8 ethyl 4-iodobutyrate 
• 23583-21-3 ethyl-3-benzylamino propionate 

Downstream Products

• 49569-46-2 1-benzyl-5-bromohexahydroazepin-4-one hydrobromide 
• 26735-10-4 4-(benzylamino)butanoic acid 
• 109386-80-3 1-benzyl-1-azoniabicyclo<3.2.0>heptane chloride 
• 109386-79-0 1-benzyl-4-chloroperhydroazepine hydrochloride 
• 109386-81-4 1-benzyl-4-chloroperhydroazepine 
• 109162-29-0 1-benzyl-4-hydroxyhexahydro-1H-azepine 
• 1208-76-0 1-benzyl-1,2,3,5,6,7-hexahydroazepine-4-one hydrochloride 
• 1208-75-9 1-benzylazepan-4-one 
• 5291-77-0 1-benzyl-2-pyrrolidone 

Relevant academic research and scientific papers

Synthesis, structure and reactivity of a macrocyclic imine: Aza-[13]-macrodiolides

The in situ synthesis and subsequent reactions of macrocylic imine 2 are reported. The imine was trapped with cyanotrimethylsilane to give α-amino nitrile aza-[13]-macrodiolides in a 1:1 ratio of diastereomers. A crystal structure of the syn α-cyano nitrile diastereomer, 7a, provided insights into the lack of selectivity in reactions of 2 relative to macrocyclic alkene 1. Reactions to functionalize the syn diastereomer 7a are also reported.

Synthesis, structure and reactivity of a macrocyclic imine: Aza-[13]-macrodiolides

The in situ synthesis and subsequent reactions of macrocylic imine 2 are reported. The imine was trapped with cyanotrimethylsilane to give α-amino nitrile aza-[13]-macrodiolides in a 1:1 ratio of diastereomers. A crystal structure of the syn α-cyano nitrile diastereomer, 7a, provided insights into the lack of selectivity in reactions of 2 relative to macrocyclic alkene 1. Reactions to functionalize the syn diastereomer 7a are also reported.

NOVEL COMPOUNDS

The present invention relates to new CGRP-antagonists of general formula I wherein U, V, X, Y, R1, R2, R3 and R4 are defined as mentioned in the description, the tautomers thereof, the isomers thereof, the diastereomers thereof, the enantiomers thereof, the hydrates thereof, the mixtures thereof and the salts thereof as well as the hydrates of the salts, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, medicaments containing these compounds, the use thereof and processes for the preparation thereof.

HETEROCYCLIC ETHERS DERIVED FROM 6,11-DIHYDRODIBENZOTHIEPIN-11-OLS AND 4,9-DIHYDROTHIENO-2-BENZOTHIEPIN-4-OL; A NEW SERIES OF POTENTIAL ANTIDEPRESSANTS AND ANTIHISTAMINE AGENTS

Reactions of 11-chloro-6,11-dihydrodibenzothiepin and methanesulfonates of 6,11-dihydrodibenzothiepin-11-ol (I), its 2-methyl derivative II and 4,9-dihydrothieno-2-benzothiepin-4-ol (III) with 1-methylpiperidin-4-ol, 1-methylperhydroazepin-4-ol (XIX), and tropine gave the ethers V-X.Their methanesulfonates were pharmacologically tested and showed antireserpine, anticataleptic, and antihistamine activities of various degree.The most active compounds were the ethers V and VI.