120885-48-5

Basic information

• Product Name: ETHYL 2-CYANO-2-(4-CYANOPHENYL)ACETATE
• Synonyms: ETHYL 2-CYANO-2-(4-CYANOPHENYL)ACETATE
• CAS NO: 120885-48-5
• Molecular Formula: C₁₂H₁₀N₂O₂
• Molecular Weight: 214.22
• Mol File: 120885-48-5.mol

Chemical Properties

• Boiling Point: 377.4 °C at 760 mmHg
• Flash Point: 165.1 °C
• Appearance: /
• Density: 1.19 g/cm³
• CAS DataBase Reference: ETHYL 2-CYANO-2-(4-CYANOPHENYL)ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-CYANO-2-(4-CYANOPHENYL)ACETATE(120885-48-5)
• EPA Substance Registry System: ETHYL 2-CYANO-2-(4-CYANOPHENYL)ACETATE(120885-48-5)

Safety Data

• Hazardous Substances Data: 120885-48-5(Hazardous Substances Data)

Upstream product

• 3058-39-7 4-iodobenzonitrile 
• 105-56-6 ethyl 2-cyanoacetate 
• 623-03-0 4-Cyanochlorobenzene 
• 623-00-7 4-bromobenzenecarbonitrile 
• 876-31-3 4-(cyanomethyl)benzonitrile 
• 105-58-8 Diethyl carbonate 

Relevant articles and documents

Synergistic effect of a bis(proazaphosphatrane) in mild palladium-catalyzed direct α-arylations of nitriles with aryl chlorides

The effect of a bis(proazaphosphatrane) ligand on the palladium-catalyzed direct α-arylation of nitriles with various aryl chlorides under mild conditions is reported. Comparisons of the catalytic properties of this ligand with those of three related mono(proazaphosphatrane)s under the same reaction conditions revealed that bis(proazaphosphatrane) displayed a synergistically enhanced activity. In the presence of the bis(proazaphosphatrane) ligand, ethyl cyanoacetate and primary as well as secondary nitriles were efficiently coupled with a wide variety of aryl chlorides that contained electron-rich, electron-poor, and electron-neutral groups.

Synthesis of substituted isoquinolines via Pd-catalyzed cross-coupling approaches

Palladium complexes incorporating ligands based on a 1,3,5,7-tetramethyl-2, 4,8-trioxa-6-phosphaadamantanyl scaffold were used to catalyze the arylation of ethyl cyanoacetate, malononitrile, and various ketones. The products from these reactions can be el

A General Method for the Direct α-Arylation of Nitriles with Aryl Chlorides

The long-standing challenge of developing a general method for the title methodology is met for a broad range of aryl chlorides through the use of bicyclic P(iBuNCH2CH2)3N (1) as a bulky electron-rich ligand for palladium (see scheme, dba = dibenzylideneacetone).

P(i-BuNCH2CH2)3N: An efficient ligand for the direct α-arylation of nitriles with aryl bromides

A new catalyst system for the synthesis of α-aryl-substituted nitriles is reported. The bicyclic triaminophosphine P(i-BuNCH 2CH2)3N (1b) serves as an efficient and versatile ligand for the palladium-catalyzed direct α-arylation of nitriles with aryl bromides. Using ligand 1b, ethyl cyanoacetate and primary as well as secondary nitriles are efficiently coupled with a wide variety of aryl bromides possessing electron-rich, electron-poor, electron-neutral, and sterically hindered groups.

Chemistry of novel compounds possessing multifunctional carbon atoms. X. Synthetic studies of efficient and practical chiral derivatizing agents based on the α-cyano-α-fluorophenylacetic acid structure

In order to develop efficient chiral derivatizing agents (CDAs) which can be obtained readily in optically active form, synthetic studies of α-cyano- α-fluorophenylacetic acid (CFPA) analogs, 3a-e and CFNA (14a), were made. Carboxylation of 6a-e obtained

ELECTROCHEMICALLY INDUCED SRN1 AROMATIC NUCLEOPHILIC SUBSTITUTION. MONOANIONS OF β-DICARBONYL AND β-CYANOCARBONYL COMPOUNDS AS NUCLEOPHILES.

Monoanions deriving from β-dicarbonyl or β-cyanocarbonyl compounds can be used as nucleophiles in electrochemically induced SRN1 aromatic nucleophilic substitution with different substrates including cyano or benzoyl substituted aromatic halides and 2-chloroquinoline.