1208872-40-5

Upstream product

• 98-01-1 furfural 
• 5370-25-2 2-Acetyl-5-bromothiophene 
• 99866-37-2 C₁₁H₇BrO₂S 
• 1208869-43-5 ethyl 7-(5-bromothiophen-2-yl)-4,7-dioxoheptanoate 
• 108791-97-5 N-(4-amino-3-methylphenyl)methanesulfonamide 
• 611-05-2 4-nitro-3-methylaniline 
• 108791-96-4 N-(3-methyl-4-nitrophenyl)methanesulfonamide 

Downstream Products

• 1208316-94-2 3-(5-(5-(2-methyl-1H-imidazol-1-yl)thiophen-2-yl)-1-(2-methyl-4-(methylsulfonamido)phenyl)-1H-pyrrol-2-yl)propanoic acid 
• 1208872-41-6 ethyl 3-(5-(5-(2-methyl-1H-imidazol-1-yl)thiophen-2-yl)-1-(2-methyl-4-(methylsulfonamido)phenyl)-1H-pyrrol-2-yl)propanoate 

Relevant academic research and scientific papers

Structure-activity relationship of pyrrole based S-nitrosoglutathione reductase inhibitors: Carboxamide modification

The enzyme S-nitrosoglutathione reductase (GSNOR) is a member of the alcohol dehydrogenase family (ADH) that regulates the levels of S-nitrosothiols (SNOs) through catabolism of S-nitrosoglutathione (GSNO). GSNO and SNOs are implicated in the pathogenesis of many diseases including those in respiratory, gastrointestinal, and cardiovascular systems. The pyrrole based N6022 was recently identified as a potent, selective, reversible, and efficacious GSNOR inhibitor which is currently in clinical development for acute asthma. We describe here the synthesis and structure-activity relationships (SAR) of novel pyrrole based analogs of N6022 focusing on carboxamide modifications on the pendant N-phenyl moiety. We have identified potent and novel GSNOR inhibitors that demonstrate efficacy in an ovalbumin (OVA) induced asthma model in mice.