108791-96-4

Upstream product

• 611-05-2 4-nitro-3-methylaniline 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 108791-97-5 N-(4-amino-3-methylphenyl)methanesulfonamide 
• 1208872-41-6 ethyl 3-(5-(5-(2-methyl-1H-imidazol-1-yl)thiophen-2-yl)-1-(2-methyl-4-(methylsulfonamido)phenyl)-1H-pyrrol-2-yl)propanoate 
• 1208872-40-5 ethyl 3-(5-(5-bromothiophen-2-yl)-1-(2-methyl-4-(methylsulfonamido)phenyl)-1H-pyrrol-2-yl)propanoate 
• 1208316-62-4 3-(5-(4-(2-methyl-1H-imidazol-1-yl)phenyl)-1-(2-methyl-4-(methylsulfonamido)phenyl)-1H-pyrrol-2-yl)propanoic acid 
• 1208316-93-1 3-(5-(4-(2-methyl-1H-imidazol-1-yl)thiophen-2-yl)-1-(2-methyl-4-(methylsulfonamido)phenyl)-1H-pyrrol-2-yl)propanoic acid 
• 1208316-94-2 3-(5-(5-(2-methyl-1H-imidazol-1-yl)thiophen-2-yl)-1-(2-methyl-4-(methylsulfonamido)phenyl)-1H-pyrrol-2-yl)propanoic acid 
• 1208872-37-0 C₂₅H₂₈N₄O₄S₂ 
• 108792-00-3 4-dichloroacetamido-3-methyl-N-methanesulphonyl aniline 
• 108792-03-6 2,2-Dichloro-N-[4-[(E)-methanesulfonylimino]-2-methyl-cyclohexa-2,5-dien-(E)-ylidene]-acetamide 
• 108792-06-9 3-methyl-4-pivalamido-N-methanesulphonyl aniline 
• 108792-14-9 N-[4-[(E)-Methanesulfonylimino]-2-methyl-cyclohexa-2,5-dien-(E)-ylidene]-2,2-dimethyl-propionamide 

Relevant academic research and scientific papers

COMPOUNDS FOR INHIBITING TNIK AND MEDICAL USES THEREOF

The present disclosure provides the compound having inhibitory property against TNIK having a specific chemical structure or its pharmaceutically acceptable salt. The present disclosure also provides a composition comprising the compound or its pharmaceutically acceptable salt. The present disclosure also provides a medical use of the compound, its salt or the composition comprising the compound or its pharmaceutically acceptable salt for treating or preventing cancer. The present disclosure also provides a method of treatment or prevention of cancer comprising administering the compound, its salt or the composition comprising the compound or its salt to a subject in need of such treatment or prevention.

Structure-activity relationship of pyrrole based S-nitrosoglutathione reductase inhibitors: Carboxamide modification

The enzyme S-nitrosoglutathione reductase (GSNOR) is a member of the alcohol dehydrogenase family (ADH) that regulates the levels of S-nitrosothiols (SNOs) through catabolism of S-nitrosoglutathione (GSNO). GSNO and SNOs are implicated in the pathogenesis of many diseases including those in respiratory, gastrointestinal, and cardiovascular systems. The pyrrole based N6022 was recently identified as a potent, selective, reversible, and efficacious GSNOR inhibitor which is currently in clinical development for acute asthma. We describe here the synthesis and structure-activity relationships (SAR) of novel pyrrole based analogs of N6022 focusing on carboxamide modifications on the pendant N-phenyl moiety. We have identified potent and novel GSNOR inhibitors that demonstrate efficacy in an ovalbumin (OVA) induced asthma model in mice.

QUINONE-IMIDES : REGIOSPECIFICITY OF NUCLEOPHILIC ATTACK ON N-ALKANESULPHONYL-N'-ALKANOYL 1,4-BENZOQUINONE-IMINES.

Substrates such as (2) undergo regiospecific attack by azide and thiocyanate ions at the terminus of the C=C-C=N-CO system.In the case of addition of azide, this is proved by the detailed analysis of the 1H and 13C NMR spectra of the products (11) derived from the quinone-imides (8).The structure of the products obtained by the addition of thiocyanate to the quinone-imides (10) and (20) is proved by their facile cyclisation to the 2-aminobenzothiazoles (18) and (21) respectively.