611-05-2

Basic information

• Product Name: 3-Methyl-4-nitroaniline
• Synonyms: 3-METHYL-4-NITRO-PHENYLAMINE;3-METHYL-4-NITROBENZENEAMINE;3-METHYL-4-NITROANILINE;3-Amino-6-nitrotoluene;5-AMINO-2-NITROTOLUENE;4-AMINO-3-METHYL-4-NITROBENZENE;4-NITRO-M-TOLUIDINE;4-nitro-3-methylaniline
• CAS NO: 611-05-2
• Molecular Formula: C₇H₈N₂O₂
• Molecular Weight: 152.15
• EINECS: 210-247-8
• Product Categories: Aromatics Compounds;Functional Materials;Organic Nonlinear Optical Materials;Aromatics
• Mol File: 611-05-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 136-137°C
• Boiling Point: 330 °C at 760 mmHg
• Flash Point: 153.4 °C
• Appearance: brown crystalline solid
• Density: 1.269 g/cm³
• Vapor Pressure: 0.000171mmHg at 25°C
• Refractive Index: 1.615
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: Methanol
• PKA: 1.12±0.10(Predicted)
• BRN: 2209112
• CAS DataBase Reference: 3-Methyl-4-nitroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methyl-4-nitroaniline(611-05-2)
• EPA Substance Registry System: 3-Methyl-4-nitroaniline(611-05-2)

Safety Data

• Hazard Codes: T
• Statements: 23/24/25-33-51/53
• Safety Statements: 28-36/37-45-61
• RIDADR: 2660
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 611-05-2(Hazardous Substances Data)

Usage

Chemical Properties

Brown Crystalline Solid

Uses

3-Methyl-4-nitrobenzeneamine (cas# 611-05-2) is a compound useful in organic synthesis.

Synthesis Reference(s)

Synthetic Communications, 18, p. 2161, 1988 DOI: 10.1080/00397918808068287

InChI:InChI=1/C7H8N2O2/c1-5-4-6(8)2-3-7(5)9(10)11/h2-4H,8H2,1H3

Upstream product

• 36164-91-7 toluquinone dioxime 
• 7664-93-9 sulfuric acid 
• 108-44-1 1-amino-3-methylbenzene 
• 4478-10-8 2-bromo-1-isopropyl-4-methyl-benzene 
• 99584-85-7 3-methyl-4-nitro benzamide 
• 408328-19-8 2-nitro-5-nitrosotoluene 
• 7647-01-0 hydrogenchloride 
• 204254-68-2 4-methyl-5-nitro-anthranilic acid 
• 619-15-8 2,5-dinitrotoluene 
• 7664-41-7 ammonia 
• 52177-06-7 4-ethoxy-2-methyl-1-nitrobenzene 
• 3085-53-8 N-formyl-m-toluidine 
• 7697-37-2 nitric acid 
• 97055-50-0 1,6-Dimethyl-3,5-dinitro-2-pyridone 

Downstream Products

• 51366-39-3 4-acetamido-2-methylnitrobenzene 
• 104478-89-9 2,2-Dimethyl-N-(3-methyl-4-nitro-phenyl)-propionamide 
• 108791-96-4 N-(3-methyl-4-nitrophenyl)methanesulfonamide 
• 95-70-5 2-methyl-p-phenylenediamine 
• 6375-20-8 N-(4-Amino-3-methyl-phenyl)-acetamide 
• 1208318-94-8 1-amino-(2-methyl-4-(sulfamoylamino)phenyl) 
• 112768-01-1 4-bromo-1-nitro-2-vinylbenzene 
• 105205-48-9 [(E)-2-(5-bromo-2-nitro-phenyl)-vinyl]-dimethyl-amine 
• 92856-53-6 2-Nitro-5-benzylmercapto-phenylbrenztraubensaeure 
• 858713-01-6 5-methyl-[6]quinolylamine 
• 77094-10-1 6-amino-7-methylquinoline 
• 5400-77-1 2,6-diiodo-3-methyl-4-nitro-aniline 
• 5411-52-9 4,5,6-triiodo-2-nitrotoluene 
• 99-52-5 2-methyl-4-nitro-benzenamine 

Relevant articles and documents

Pyrrole inhibitors of S-nitrosoglutathione reductase as therapeutic agents

The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same.

Synthesis of symmetric dinitro-functionalised troeger's base analogues

The synthesis of six new examples of 2,8-dinitro-substituted Troeger's base analogues are reported, together with the first examples of 1,7-, 3,9- and 4,10-dinitro Troeger's base analogues and the first example of a tetranitro Troeger's base compound. Several of these dinitro compounds lack substituents at the 2- and 8-positions and therefore provide further examples of Troeger's base analogues derived from anilines lacking a para substituent.

REGIOSELECTIVE SYNTHESIS OF 2-SUBSTITUTED 3-NITROPYRIDINES BY ONE-POT REACTION OF EITHER 4- OR 6-SUBSTITUTED 1-METHYL-3,5-DINITRO-2-PYRIDONES WITH KETONES AND AMMONIA

Regioselective synthesis of 2-substituted 3-nitropyridines was achieved by one-pot reaction of either 4- or 6-substituted 1-methyl-3,5-dinitro-2-pyridones with ketones in the presence of ammonia.The selectivity is interpreted in terms of steric factor of substituent on the pyridone.