120963-50-0

Basic information

• Product Name: 5-[(E)-2-bromoethenyl]-1-[(1S,3R,4S)-3-hydroxy-4-(hydroxymethyl)cyclopentyl]pyrimidine-2,4(1H,3H)-dione
• Synonyms: 2,4(1H,3H)-pyrimidinedione, 5-[(E)-2-bromoethenyl]-1-[(1S,3R,4S)-3-hydroxy-4-(hydroxymethyl)cyclopentyl]-
• CAS NO: 120963-50-0
• Molecular Formula: C₁₂H₁₅BrN₂O₄
• Molecular Weight: 331.1625
• Mol File: 120963-50-0.mol
• Article Data: 5

Chemical Properties

• Density: 1.758g/cm³
• Refractive Index: 1.702
• CAS DataBase Reference: 5-[(E)-2-bromoethenyl]-1-[(1S,3R,4S)-3-hydroxy-4-(hydroxymethyl)cyclopentyl]pyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[(E)-2-bromoethenyl]-1-[(1S,3R,4S)-3-hydroxy-4-(hydroxymethyl)cyclopentyl]pyrimidine-2,4(1H,3H)-dione(120963-50-0)
• EPA Substance Registry System: 5-[(E)-2-bromoethenyl]-1-[(1S,3R,4S)-3-hydroxy-4-(hydroxymethyl)cyclopentyl]pyrimidine-2,4(1H,3H)-dione(120963-50-0)

Safety Data

• Hazardous Substances Data: 120963-50-0(Hazardous Substances Data)

Upstream product

• 91661-15-3 (E)-3-<1,2,3,4-tetrahydro-1-<3α-hydroxy-4β-(hydroxymethyl)cyclopentan-1-yl>-2,4-dioxopyrimidin-5-yl>propenoic acid 
• 120963-42-0 (-)-3-ethoxy-N-cyclopentyl>carbamoyl>propenamide 
• 120963-37-3 (+)-(1S,2S,4S)-2-<(benzoyloxy)methyl>-4-<(benzyloxy)methyl>cyclopentyl methanesulfonate 
• 120963-38-4 (-)-<(1S,2R,4S)-2-acetoxy-4-<(benzyloxy)methyl>cyclopentyl>methyl benzoate 
• 120963-47-5 (-)-1-<(1S,3R,4S)-3-hydroxy-4-(hydroxymethyl)cyclopentyl>-5-<(E)-2-carbomethoxyvinyl>-1H,3H-pyrimidine-2,4-dione 
• 120963-41-9 (-)-(1S,3R,4S)-N-<3-acetoxy-4-<(benzoyloxy)methyl>cyclopentyl>urea 
• 120963-36-2 (+)-<(1S,2S,4S)-4-<(benzyloxy)methyl>-2-hydroxycyclopentyl>methyl benzoate 
• 120963-40-8 (-)-(1S,3R,4S)-3-acetoxy-4-<(benzoyloxy)methyl>cyclopentanecarboxylic acid 
• 120963-39-5 (-)-(1S,3R,4S)-3-acetoxy-4-<(benzoyloxy)methyl>cyclopentanemethanol 
• 120963-45-3 (-)-1-<(1S,3R,4S)-3-hydroxy-4-(hydroxymethyl)cyclopentyl>-5-iodo-1H,3H-pyrimidine-2,4-dione 
• 120963-44-2 (-)-1-<(1S,3R,4S)-3-hydroxy-4-(hydroxymethyl)cyclopentyl>-1H,3H-pyrimidine-2,4-dione 
• 120963-35-1 (+)-(1S,2S,4S)-4-<(benzyloxy)methyl>-2-hydroxycyclopentanemethanol 
• 120963-49-7 (E)-3-[1-((1S,3R,4S)-3-Hydroxy-4-hydroxymethyl-cyclopentyl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-acrylic acid 
• 62102-28-7 1-<3α-hydroxy-4β-(hydroxymethyl)-cyclopentan-1-yl>pyrimidine-2,4-(1H,3H)-dione 

Relevant articles and documents

Cyclopentane-nucleobase coupling in the synthesis of carbocyclic L-nucleosides: Is a SN2-reaction an alternative to the mitsunobu-reaction?

Several carbocyclic L-nucleosides have been synthesized by coupling a cyclopentane-system with heterocycles according to a modified Mitsunobu-protocol. This reaction gave two regioisomers, the N1-alkylated product and an unwanted O2-product. A simple SN2-reaction has been investigated as an alternative for such couplings. Copyright Taylor & Francis Group, LLC.

Synthesis and Antiviral Activity of the Enantiomeric Forms of Carba-5-iodo-2'-deoxyuridine and Carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine

Both enantiomers of the carbocyclic analogues of 5-iodo-2'-deoxyuridine (14 and ent-14) and of (E)-5-(2-bromovinyl)-2'-deoxyuridine (16 and ent-16) were synthesized by using (+)- or (-)-endo-norborn-5-en-2-yl acetate or butyrate, respectively, as starting

5-Halovinyl-2'-deoxyuridine derivatives

Compounds of general formula (I): STR1 wherein R is a chlorine, bromine or iodine atom and physiologically acceptable salts thereof with bases of use as antiviral agents.