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Usage

Uses

Used in Pharmaceutical Applications:
Ethanone, 1-(2-pyrrolidinyl)-, (S)(9CI) is used as a building block in the synthesis of other compounds for pharmaceutical applications. Its unique structure and chiral nature contribute to the development of new drugs with specific biological activities and interactions.
Used in Research and Development:
In the field of research and development, Ethanone, 1-(2-pyrrolidinyl)-, (S)(9CI) is utilized for its potential uses in drug discovery, material science, and other areas. Its unique properties and chiral nature make it a valuable compound for exploring new applications and advancing scientific understanding.
Used in Material Science:
Ethanone, 1-(2-pyrrolidinyl)-, (S)(9CI) is employed in material science for its potential applications in the development of new materials with specific properties. Its unique structure and chiral nature can contribute to the creation of innovative materials with tailored characteristics for various industries.

Upstream product

• 91550-08-2 (S)-2-acetylpyrrolidine-1-carboxylic acid tert-butyl ester 
• 115186-37-3 tert-butyl (2S)-2-{[N-methoxy(N-methyl)amino]carbonyl}pyrrolidine-1-carboxylate 

Relevant academic research and scientific papers

Total Synthesis of the Highly N-Methylated Acetylene-Containing Anticancer Peptide Jahanyne

The first total synthesis of the highly N-methylated acetylene-containing lipopeptide jahanyne, an apoptosis-inducing natural product from marine cyanobacteria, is reported. A late-stage solution-phase coupling enabled introduction of the C-terminal keton

Ketopyrrolidines and ketoazetidines as potent dipeptidyl peptidase IV (DPP IV) inhibitors

In this paper the synthesis and structure-activity relationships of two classes of electrophile-based DPP IV inhibitors, the ketopyrrolidines and ketoazetidines, is discussed. The in vitro potency, stability and ex vivo experiments were performed on select compounds within these series to determine their inhibitory capacity in plasma. In this paper, the synthesis and structure-activity relationships (SAR) of two classes of electrophile-based dipeptidyl peptidase IV (DPP IV) inhibitors, the ketopyrrolidines and ketoazetidines, is discussed. The SAR of these series demonstrate that the 2-thiazole, 2-benzothiazole, and 2-pyridylketones are optimal S1′ binding groups for potency against DPP IV. In addition, both cyclohexyl glycine (CHG) and octahydroindole carboxylate (OIC) serve as the most potent S2 binding groups within each series. Stereochemistry at the α-position of the central ring is relevant to potency within the ketopyrrolidines series, but not in the ketoazetidine series. Finally, the ketoazetidines display enhanced stability over the corresponding ketopyrrolidines, while maintaining their potency. In fact, certain stabilized ketoazetidines can maintain their in vitro potency and inhibit DPP IV in the plasma for up to 6 h.