120979-98-8Relevant academic research and scientific papers
Synthesis of natural 5,7-dihydroxy-3-(4-hydroxybenzyl)chromone and its congener
Jain, A. C.,Paliwal, Poonam
, p. 416 - 418 (2007/10/02)
2-Hydroxy-4,6-dibenzyloxyacetophenone (1) on condensation with p-benzyloxybenzaldehyde (2a) or veratraldehyde (2b) gives the corresponding chalcone (3a or 3b) which is reduced to dihydrochalcone (4a or 4b).The latter undergoes cyclization with DMF in the presence of borontrifluoride etherate and methanesulphonyl chloride to give 5,7-dihydroxy-3-(4-hydroxybenzyl)chromone (5a), identical with naturally occuring compound, or 5,7-dihydroxy-3-(3,4-dimethoxybenzyl)chromone (5b).
