124281-56-7

Upstream product

• 124281-55-6 2',4',6'-Trihydroxy-3,4-dimethoxydihydrochalcone 
• 124-63-0 methanesulfonyl chloride 
• 18065-05-9 1-[2,4-bis(benzyloxy)-6-hydroxyphenyl]ethanone 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 480-66-0 2,4,6-trihydroxyacetophenone 
• 120979-98-8 4',6'-Dibenzyloxy-2'-hydroxy-3,4-dimethoxychalcone 

Relevant academic research and scientific papers

New homoisoflavonoid analogues protect cells by regulating autophagy

As a special group of naturally occurring flavonoids, homoisoflavonoids have been discovered as active components of several traditional Chinese medicines for nourishing heart and mind. In this study, twenty homoisoflavonoid analogues, including different substitution groups on rings A and B, as well as heteroaromatic B ring, were synthesized and evaluated for their cardioprotective and neuroprotective activities. In a H2O2-induced H9c2 cardiomyocytes injury assay, nine homoisoflavonoid analogues showed promising activities in the same level as the positive control, diazoxide. Six cardioprotective compounds with representative structure diversities were then evaluated for their neuroprotective effects on MPP+ induced SH-SY5Y cell injury model. Furthermore, autophagy inducing monodansylcadaverine (MDC) fluorescence staining methods and molecular docking studies indicated the action mechanism of these compounds may involve autophagy regulating via class I PI3K signaling pathway.

Synthesis of natural 5,7-dihydroxy-3-(4-hydroxybenzyl)chromone and its congener

2-Hydroxy-4,6-dibenzyloxyacetophenone (1) on condensation with p-benzyloxybenzaldehyde (2a) or veratraldehyde (2b) gives the corresponding chalcone (3a or 3b) which is reduced to dihydrochalcone (4a or 4b).The latter undergoes cyclization with DMF in the presence of borontrifluoride etherate and methanesulphonyl chloride to give 5,7-dihydroxy-3-(4-hydroxybenzyl)chromone (5a), identical with naturally occuring compound, or 5,7-dihydroxy-3-(3,4-dimethoxybenzyl)chromone (5b).