1869-22-3

Usage

Uses

Used in Organic Synthesis:
1-[2-Chloro-5-(trifluoromethyl)phenyl]hydrazine is used as a synthetic intermediate for the preparation of various organic compounds. Its unique functional groups allow for a range of chemical reactions, making it a valuable building block in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1-[2-Chloro-5-(trifluoromethyl)phenyl]hydrazine is used as a key component in the development of new drugs. Its specific structural features can be exploited to design and synthesize pharmaceutical agents with targeted therapeutic effects.
Used in Agrochemicals:
1-[2-Chloro-5-(trifluoromethyl)phenyl]hydrazine is also utilized in the agrochemical sector as a precursor for the synthesis of various agrochemical products. Its unique properties can contribute to the development of effective pesticides, herbicides, or other agricultural chemicals.

Upstream product

• 98-38-4 2-Chloro-5-trifluoromethyl-benzenediazonium; chloride 
• 121-50-6 3-amino-4-chlorobenzotrifluoride 
• 328-84-7 1,2-dichloro-4-(trifluoromethyl)benzene 

Downstream Products

• 96423-46-0 N-(2-Chloro-5-trifluoromethyl-phenyl)-N'-(4,5-dihydro-thiazol-2-yl)-hydrazine; hydrobromide 
• 96423-58-4 N-(2-Chloro-5-trifluoromethyl-phenyl)-N'-(5,6-dihydro-4H-[1,3]thiazin-2-yl)-hydrazine; hydrochloride 
• 23152-52-5 C₉H₉ClF₃N₃O 
• 24095-89-4 C₉H₉ClF₃N₃S 
• 39885-50-2 2-chloro-4-(trifluoromethyl)aniline 
• 121-50-6 3-amino-4-chlorobenzotrifluoride 

Relevant academic research and scientific papers

Discovery of a polysubstituted phenyl containing novel N-phenylpyrazole scaffold as potent ryanodine receptor activator

To develop the novel ryanodine receptors (RyRs) insecticides, encouraged by our previous research work, a series of novel N-phenylpyrazole derivatives containing a polysubstituted phenyl ring scaffold were designed and synthesized. The bioassays results i

Anthranilic diamides derivatives as potential ryanodine receptor modulators: Synthesis, biological evaluation and structure activity relationship

A series of novel anthranilic diamides derivatives (7a–s) containing halogen, trifluoromethyl group and cyano group were designed, synthesized, and characterized by melting point, 1H NMR, 13C NMR and elemental analyses. The bioactivity revealed that most of them showed moderate to excellent activities against oriental armyworm (Mythimna separata) and diamondback moth (Plutella xylostella). Above all, the larvicidal activity of 7o against oriental armyworm was 100% and 40% at 0.25 and 0.1 mg L?1, comparable to that of the standard chlorantraniliprole (100%, 0.25 mg L?1 and 20%, 0.1 mg L?1). What is more, 7o against diamondback moth displayed 90% insecticidal activity at 0.01 mg L?1, superior to chlorantraniliprole (45%, 0.01 mg L?1). The experiments 7o on the American cockroach (Periplaneta Americana) heart beating rates (Dorsal vessel) and contractile force were compared with chlorantraniliprole. In addition, 7o could affect the calcium homeostasis in the central neurons of the third larvae of oriental armyworm, which revealed that the ryanodine receptor is the potential target of 7o. The density functional theory (DFT) calculation results revealed the amide bridge, the benzene ring of anthraniloyl moiety and pyrazole ring might play an important role in the insecticidal activity through hydrophobic interactions and π-π conjugations.

Processes for preparing pesticidal intermediates

Compounds of formula (I) are prepared by hydrogenolysis of a compound of formula (II): where R1is haloalkyl, haloalkoxy or ?SF5; W is N or CR3; and R2and R3are H or Cl. The compounds of formula (I) can be used as intermediates in the preparation of pesticidally active arylpyrazole compounds.

Use of phenyl hydrazines for seed biostimulation or the treatment of lipoxygenase mediated seed deteriorations

The present invention provides a method of treating certain deleterious conditions mediated by the action of lipoxygenases in mammals and seeds using certain phenyl hydrazines. Also provided is a method for seed biostimulation using these phenyl hydrazines.

Antiimplantation Agents: Part I - 1-Arylthiosemicarbazides

Several 1-arylthiosemicarbazides, 2-arylhydrazinothiazolines and 2-arylhydrazinodihydrothiazines have been examined for their antiimplantation activity in rats.Among the active compounds, 4-methyl-1-(3,5-bistrifluoromethylphenyl)thiosemicarbazide (3, C 2696-Go) and the corresponding 4,4-dimethyl (47), ethyl (4), n-butyl (5) and allyl (6) derivatives completely inhibit implantation at doses 10, 3, 20, 20 and 30 mg/kg respectively.The 3,4-dichlorophenyl analogue (32) is effective at a dose of 30 mg/kg. 2-(3,5-Bistrifluoromethylphenyl)hydrazinothiazoline (51) and the corresponding dihydrothiazine (63) show a weaker activity.The biological profile of C 2696-Go has been investigated in detail.It appears to prevent implantation by its antiuterotropic activity and ability to inhibit desiduoma formation.