1210-92-0

Basic information

• Product Name: Diethyl 1-Methylimidazole-4,5-dicarboxylate
• Synonyms: Diethyl 1-Methylimidazole-4,5-dicarboxylate;1-Methyl-1H-imidazole-4,5-dicarboxylic acid diethyl ester
• CAS NO: 1210-92-0
• Molecular Formula: C10H14N2O4
• Molecular Weight: 226
• Mol File: 1210-92-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Diethyl 1-Methylimidazole-4,5-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Diethyl 1-Methylimidazole-4,5-dicarboxylate(1210-92-0)
• EPA Substance Registry System: Diethyl 1-Methylimidazole-4,5-dicarboxylate(1210-92-0)

Safety Data

• Hazardous Substances Data: 1210-92-0(Hazardous Substances Data)

Usage

General Description

Diethyl 1-Methylimidazole-4,5-dicarboxylate is an organic compound that belongs to the class of imidazole derivatives. It consists of a central imidazole ring with two carboxylate groups and a methyl group attached. This chemical is commonly used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. Its unique structure and reactivity make it a versatile molecule for use in organic synthesis. Additionally, it is known for its potential biological activities and has been studied for its pharmacological properties. However, it is important to handle this compound with caution as it may be hazardous if not used properly.

Upstream product

• 64-17-5 ethanol 
• 42190-84-1 1-methyl-4,5-imidazoledicarbonyl chloride 
• 762-21-0 acetylenedicarboxylic acid diethyl ester 
• 19485-35-9 1-methyl-4,5-dicyanoimidazole 
• 1122-28-7 4,5-dicyano-1H-imidazole 
• 19485-38-2 1-methyl-1H-imidazole-4,5-dicarboxylic acid 
• 570-22-9 4,5-imidazoledicarboxylic acid 
• 1080-79-1 imidazole 4,5-dicarboxylic acid diethyl ester 
• 74-88-4 methyl iodide 

Downstream Products

• 202278-29-3 1,7-dimethyl-1,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one 
• 5422-71-9 4,7-dichloro-1-methyl-1H-imidazo[4,5-d]pyridazine 
• 263159-47-3 N-[4,5-bis(tert-butyldimethylsilyloxymethyl)-1-methyl-1H-imidazol-2-yl]-N-tritylamine 
• 263159-48-4 N-[4,5-bis(hydroxymethyl)-1-methyl-1H-imidazol-2-yl]-N-tritylamine 

Relevant articles and documents

AZOLE-FUSED PYRIDAZIN-3(2H)-ONE DERIVATIVES

Disclosed are compounds of Formula (1) and pharmaceutically acceptable salts thereof, wherein α, β, n, R4, R5, R6, R8, R9, R10, R11, X1, X2, X3 and X7 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula (1), to pharmaceutical compositions comprising them, and to their use for treating diseases, disorders, and conditions associated with GPR139.

A direct cycloaminative approach to imidazole derivatives via dual C-H functionalization

Organoiodine(III)-promoted C(sp3)-H azidation was a key step for the cycloaminative process. An unprecedented method for metal-free dehydrogenative N-incorporation into C(sp3)-H and C(sp2)-H bonds for the synthesis of diverse imidazoles has been disclosed. The overall transformation involves the construction of four C-N bonds through hydroamination-azidation-cyclization sequence. The reaction can be easily handled and proceeds under mild conditions. Further, the potential of the present strategy is revealed by the practical synthesis of N-heterocyclic carbene (NHC) precursors.

A new synthesis of carmethizole and related nitrogen analogues

A new efficient six-step synthesis of carmethizole, a novel big- carbamate alkylating agent, and syntheses of related nitrogen analogues are described, using a key 4,5-disubstituted imidazole intermediate 8.