1080-79-1

Basic information

• Product Name: Diethyl 1H-imidazole-4,5-dicarboxylate
• Synonyms: DIETHYL 1H-IMIDAZOLE-4,5-DICARBOXYLATE;DIETHYL 4,5-IMIDAZOLE-1H-4,5-DICARBOXYLATE;Diethyl 1H-imidazole-4,5-dicarboxylate 98%;DIETHYL(IMIDAZOLE-1H)-4,5-DICARBOXYLATE;1H-imidazole-4,5-dicarboxylic acid diethyl ester;1,2-diethyl 2,3-dihydro-1H-pyrazole-1,2-dicarboxylate;iethyl 1H-imidazole-4,5-dicarboxylate;1H-Imidazole-4,5-dicarboxylic acid, 4,5-diethyl ester
• CAS NO: 1080-79-1
• Molecular Formula: C₉H₁₂N₂O₄
• Molecular Weight: 212.2
• Product Categories: blocks;Carboxes;Imidazoles
• Mol File: 1080-79-1.mol
• Article Data: 13

Chemical Properties

• Melting Point: 210-216
• Boiling Point: 357.86 °C at 760 mmHg
• Flash Point: 170.228 °C
• Appearance: /
• Density: 1.25 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.605
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 8.70±0.10(Predicted)
• CAS DataBase Reference: Diethyl 1H-imidazole-4,5-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Diethyl 1H-imidazole-4,5-dicarboxylate(1080-79-1)
• EPA Substance Registry System: Diethyl 1H-imidazole-4,5-dicarboxylate(1080-79-1)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 1080-79-1(Hazardous Substances Data)

Usage

General Description

Diethyl 1H-imidazole-4,5-dicarboxylate is a chemical compound with the molecular formula C11H14N2O4. It is a derivative of imidazole, a five-membered heterocyclic compound containing 3 carbon atoms, 2 nitrogen atoms, and 2 double bonds. This particular compound consists of two ester groups, making it an ester derivative of imidazole-4,5-dicarboxylic acid. It is often used as a precursor in the synthesis of pharmaceuticals and other organic compounds due to its reactivity and functionality. Additionally, it may also have potential applications in the field of medicinal chemistry and drug discovery.

InChI:InChI=1/C12H10BrNO/c13-11-6-12(8-14-7-11)15-9-10-4-2-1-3-5-10/h1-8H,9H2

Upstream product

• 570-22-9 4,5-imidazoledicarboxylic acid 
• 64-17-5 ethanol 
• 50-00-0 formaldehyd 
• 59743-08-7 diethyl 2,3-dioxosuccinate 
• 87-91-2 diethyl (2R,3R)-tartrate 
• 78595-41-2 1,6-diethoxycarbonyldiimidazo<1,5-a; 1',5'-d>pyrazine-5,10-dione 
• 69039-88-9 diethyl 2-mercapto-4,5-imidazoledicarboxylate 
• 100-97-0 hexamethylenetetramine 

Downstream Products

• 1210-92-0 diethyl 1-methylimidazol-1H-yl-4,5-dicarboxylate 
• 131727-38-3 N-(phenyl)-N-[1-(2-(4,5-diethoxycarbonyl-1H-imidazol-1-yl)-ethyl)-4-methoxycarbonyl-4-piperidinyl]-propanamide 
• 202278-29-3 1,7-dimethyl-1,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one 
• 5422-71-9 4,7-dichloro-1-methyl-1H-imidazo[4,5-d]pyridazine 
• 68120-00-3 1-(3,4-dichloro-benzyl)-1H-imidazole-4,5-dicarboxylic acid diethyl ester 
• 6293-09-0 5,6-dihydro-1H-imidazo[4,5-d]pyridazine-4,7-dione 
• 33457-07-7 1-benzyl-4,5-di-(hydroxymethyl)imidazole 
• 148320-44-9 1-benzyl-4,5-di-(chloromethyl)imidazole 
• 773099-17-5 2-bromo-1H-imidazole-4,5-dicarboxylic acid 
• 263159-47-3 N-[4,5-bis(tert-butyldimethylsilyloxymethyl)-1-methyl-1H-imidazol-2-yl]-N-tritylamine 

Relevant articles and documents

A new synthesis of carmethizole and related nitrogen analogues

A new efficient six-step synthesis of carmethizole, a novel big- carbamate alkylating agent, and syntheses of related nitrogen analogues are described, using a key 4,5-disubstituted imidazole intermediate 8.

Synthesis of [1,3, NH2-15N3] (5′S)-8,5′-cyclo-2′-deoxyguanosine

To facilitate NMR studies and low-level detection in biological samples by mass spectrometry, [1,3, NH2-15N3] (5′S)-8,5′-cyclo-2′-deoxyguanosine was synthesized from imidazole-4,5-dicarboxylic acid in 21 steps. The three

Monocyclic L-nucleosides, analogs and uses thereof

Novel monocyclic L- nucleoside compounds have general formula (I). Embodiments of these compounds are contemplated to be useful in treating a wide variety of diseases including infections, infestations, neoplasms, and autoimmune diseases. Viewed in terms of mechanism, embodiments of the novel compounds show immunomodulatory activity, and are expected to be useful in modulating the cytokine pattern, including modulation of Th 1 and Th 2 response.