121001-06-7

Basic information

• Product Name: 2-Cyano-6-nitroanisole
• Synonyms: 2-Cyano-6-nitroanisole;2-Methoxy-3-nitrobenzonitrile
• CAS NO: 121001-06-7
• Molecular Formula: C₈H₆N₂O₃
• Molecular Weight: 178.14484
• Mol File: 121001-06-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 104-105 °C
• Boiling Point: 328.2±27.0 °C(Predicted)
• Appearance: /
• Density: 1.32±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 2-Cyano-6-nitroanisole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyano-6-nitroanisole(121001-06-7)
• EPA Substance Registry System: 2-Cyano-6-nitroanisole(121001-06-7)

Safety Data

• Hazardous Substances Data: 121001-06-7(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Canadian Journal of Chemistry, 67, p. 220, 1989 DOI: 10.1139/v89-037

Upstream product

• 28177-79-9 2-nitro-6-cyanophenol 
• 74-88-4 methyl iodide 
• 85-38-1 3-nitrosalicylic acid 
• 22621-41-6 2-hydroxy-3-nitro-benzoic acid methyl ester 
• 121001-03-4 3-nitrosoveratrole 
• 2785-95-7 3-lithio-1,2-dimethoxybenzene 
• 6299-67-8 2,3-dimethoxyaniline 
• 91-16-7 1,2-dimethoxybenzene 
• 722538-98-9 2-methoxy-3-nitrobenzamide 
• 90564-26-4 2-methoxy-3-nitro-benzoic acid methyl ester 
• 2554-86-1 2-methoxy-3-nitro-benzoyl chloride 
• 40751-88-0 2-methoxy-3-nitrobenzoic acid 

Downstream Products

• 725718-10-5 3-amino-2-methoxybenzonitrile 

Relevant articles and documents

TYK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Nucleophilic photosubstitutions of o-methoxynitrobenzenes

We report a new synthesis of 3-nitroveratrole, based on the directed lithiation of veratrole, and photochemical substitutions of both 3-nitroveratrole and o-nitroanisole with several nucleophiles.Both aromatic substrates undergo photocyanation meta to the nitro group.With hydroxide ion, 3-nitroveratrole reacts meta to the nitro group, but 2-nitroanisole undergoes replacement of either substituent, the proportion of reaction at each site depending upon the OH(-) concentration. 3-Nitroveratrole undergoes an inefficient reaction with butylamine at each methoxy group; this reaction is apparently second order in amine.The reaction between o-nitroanisole and diethylamine results only in photohydrolysis.Keywords: photosubstitution, nucleophilic, 3-nitroveratrole, o-nitroanisole