2-Cyano-6-nitroanisole

Base Information

• Chemical Name: 2-Cyano-6-nitroanisole
• CAS No.: 121001-06-7
• Molecular Formula: C₈H₆N₂O₃
• Molecular Weight: 178.147
• Hs Code.: 2926907090
• Mol file: 121001-06-7.mol

Synonyms:2-methoxy-3-nitrobenzonitrile

Chemical Property of 2-Cyano-6-nitroanisole

Chemical Property:

• Melting Point: 104-105 °C
• Boiling Point: 328.2±27.0 °C(Predicted)
• Density: 1.32±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

2-Methoxy-3-nitrobenzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Cyano-6-nitroanisole

There total 12 articles about 2-Cyano-6-nitroanisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-nitro-6-cyanophenol (28177-79-9) + methyl iodide (74-88-4) → 2-methoxy-3-nitrobenzonitrile (121001-06-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 - 25 ℃; for 24h;

Reference yield: 68.0%

2-methoxy-3-nitrobenzamide (722538-98-9) → 2-methoxy-3-nitrobenzonitrile (121001-06-7)

Guidance literature:

With pyridine; trifluoroacetic anhydride; In 1,4-dioxane; at 20 - 25 ℃; for 3h;

Reference yield:

2-methoxy-3-nitro-benzoic acid methyl ester (90564-26-4) → 2-methoxy-3-nitrobenzonitrile (121001-06-7)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium carbonate; ethanol

2: thionyl chloride

3: aqueous ammonia

4: phosphorus (V)-chloride

With ammonium hydroxide; thionyl chloride; ethanol; phosphorus pentachloride; sodium carbonate;

upstream raw materials:

2-methoxy-3-nitrobenzamide

1,2-dimethoxybenzene

2,3-dimethoxyaniline

3-lithio-1,2-dimethoxybenzene

Downstream raw materials:

3-amino-2-methoxybenzonitrile

Refernces

• 1、 -. "AMIDE-SUBSTITUTED HETEROCYCLIC COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHα RESPONSES". Paragraph 00296. . Retrieved 2014/05/24.