1210045-68-3Relevant academic research and scientific papers
Metal free, I2-catalyzed [3+1+1] cycloaddition reactions to synthesize 1,2,4-trisubstituted imidazoles
Tang, Dong,Guo, Xin,Wang, Yu,Wang, Jing,Li, Jihui,Huang, Qiangwei,Chen, Baohua
, p. 5982 - 5985 (2015)
We have successfully developed an operationally simple and economical one-pot three-component cycloaddition reaction to synthesize 1,2,4-trisubstituted imidazoles by employing aldehydes, α-amino carbonyl compounds and ammonium acetate. The transformation
Acid-catalyzed synthesis of imidazole derivatives via N-phenylbenzimidamides and sulfoxonium ylides cyclization
Tian, Yuan,Qin, Mingda,Yang, Xueying,Zhang, Xueguo,Liu, Yafeng,Guo, Xin,Chen, Baohua
, p. 2817 - 2823 (2019/04/13)
A straightforward method to synthesize imidazole derivatives from amidines and sulfoxonium ylides catalyzed by acids is reported in this study. Specifically, catalyzed by trifluoroacetic acid in DCE solvents can improve synthesis efficiency under metal-fr
Copper-Catalyzed Simultaneous Activation of C-H and N-H Bonds: Three-Component One-Pot Cascade Synthesis of Multi?-substituted Imidazoles
Pardeshi, Sachin D.,Sathe, Pratima A.,Vadagaonkar, Kamlesh S.,Melone, Lucio,Chaskar, Atul C.
, p. 361 - 370 (2018/01/12)
A copper-catalyzed expedient, practical, and straightforward approach for the one-pot three-component modular synthesis of multisubstituted imidazoles has been described by using arylacetic acids, N -arylbenzamidines, and nitroalkanes. The reaction involv
One-Pot Protocol for the Synthesis of Imidazoles and Quinoxalines using N-Bromosuccinimide
Pardeshi, Sachin D.,Sathe, Pratima A.,Vadagaonkar, Kamlesh S.,Chaskar, Atul C.
supporting information, p. 4217 - 4226 (2017/12/07)
N-bromosuccinimide (NBS)-mediated one-pot, green, efficient and practical synthesis of substituted imidazoles and quinoxalines has been achieved by the reaction of styrenes with N-arylbenzamidines and o-phenylenediamines, respectively, in a water:1,4-dioxane mixture. The reaction involves formation of an α-bromo ketone as an intermediate in the presence of NBS and water, followed by condensation with the N-arylbenzamidine and o-phenylenediamine. Use of an inexpensive NBS as a bromine source as well as an oxidant, water as a solvent and readily available starting materials makes this protocol environmentally benign and economically viable. Substituted imidazoles and quinoxalines were obtained in good to excellent yields with wide functional group compatibility. (Figure presented.).
Facile synthesis of 1,2,4-trisubstituted imidazoles via aerobic copper catalyzed ligand-free [3+2] cycloaddition
Li, Wei,Tian, Weixiang Jiao Wan,Lei, Ming
, p. 386 - 392 (2014/05/20)
A simple and facile approach to highly functionalized imidazole derivatives in moderate to good yields has been developed. This method involves copper catalyzed aerobic [3+2] cycloaddition of amidines with nitroolefins in absence of ligand. Based on observation of the intermediates, possible reaction mechanism different from the same reported approach was proposed.
A one-pot, four-component synthesis of N-substituted 2,4-diarylimidazoles
Adib, Mehdi,Ansari, Samira,Feizi, Shahzad,Damavandi, Jafar Asgarian,Mirzaei, Peiman
experimental part, p. 3263 - 3266 (2010/03/03)
A one-pot, four-component synthesis of 1,2,4-trisubstituted 1H-imidazoles is described. Heating a mixture of a 2-bromoacetophenone, an aldehyde, a primary amine, and ammonium acetate under solvent-free conditions affords functionalized imidazoles in good
