1210054-74-2Relevant academic research and scientific papers
Isolation of an σ-alkyl iridium hydride complex, formed in the (semi)hydrogenation of an β-enamido ketone
Maurer, Frauke,Kazmaier, Uli
, p. 3425 - 3428 (2013)
σ-Alkyl iridium hydride complexes are generally postulated as intermediates in iridium-catalyzed hydrogenation. Fast reductive elimination results in the formation of the hydrogenation product. With an β-enamido ketone as unsaturated substrate, such an intermediate could be trapped because the semihydrogenated product coordinates trifold to the iridium, generating a stable 18e- complex, which does not eliminate.
I2-Catalyzed C-O Bond Formation and Dehydrogenation: Facile Synthesis of Oxazolines and Oxazoles Controlled by Bases
Gao, Wen-Chao,Hu, Fei,Huo, Yu-Ming,Chang, Hong-Hong,Li, Xing,Wei, Wen-Long
, p. 3914 - 3917 (2015/08/18)
A general method for the synthesis of oxazolines and oxazoles was developed through I2-catalyzed C-O bond formation and dehydrogenation with the same oxidant, TBHP. By simply tuning reaction bases, either oxazolines or oxazoles were selectively
Selective reduction of acyl aziridines to Mannich bases using silyllithium reagents
Davis, Amanda L.,Korous, Arthur A.,Hartel, Aaron M.
supporting information, p. 3673 - 3674 (2013/07/05)
Mannich bases are prepared from the selective α-reduction of acyl aziridines using silyllithium reagents. The reaction proceeds via an aziridine ring-opening assisted Brook rearrangement.
Enantioselective synthesis of optically pure β-amino ketones and γ-aryl amines by Rh-catalyzed asymmetric hydrogenation
Geng, Huiling,Huang, Kexuan,Sun, Tian,Li, Wei,Zhang, Xiaowei,Zhou, Le,Wu, Wenjun,Zhang, Xumu
, p. 332 - 334 (2011/03/19)
A series of optically pure β-amino ketones have been synthesized in high enantioselectivities (ee > 99%) by Rh-DuanPhos-catalyzed asymmetric hydrogenation of readily prepared β-keto enamides. Further reduction of these β-amino ketones with hydrogen and Pd/C leads to the formation of a variety of protected enantiomerically pure γ-aryl amines (ee > 99%), which are key building blocks in many bioactive molecules.
