121019-72-5Relevant academic research and scientific papers
Nitrile Additions to C,N-Diacylimines. Formation of 4-Amidooxazoles
Fischer, Bilha,Hassner, Alfred
, p. 5225 - 5229 (2007/10/02)
Nitriles are shown to react with C,N-diacylimines 2, generated in situ from 1 or 4 in the presence of Lewis acids, to produce 4-amidooxazoles 5 and 6 in good to excellent yield.Diamides are sometimes also produced.The reaction was followed by NMR spectros
A New Synthesis of 4-Aminooxazoles from α-Oxonitriles
Lakhan, Ram,Singh, Ram Lakhan
, p. 1413 - 1417 (2007/10/02)
A general synthesis is described for the preparation of 4-amino-2,5-disubstituted oxazoles 2.The interaction of α-oxonitriles 1 with equimolecular amounts of aromatic or aliphatic aldehydes, and excess of anhydrous ammonium acetate in glacial acetic acid at 110-120 deg C for 3-6 hours gives 2 in 40-65percent yields.A plausible reaction mechanism for the formation of 2 is also suggested.
