121032-79-9

Upstream product

• 201230-82-2 carbon monoxide 
• 104-87-0 4-methyl-benzaldehyde 
• 76539-22-5 (2-chloro-1-cyclohexen-1-yl)methanol 
• 1680-73-5 2-chlorocyclohexene-1-carboxaldehyde 

Downstream Products

• 121032-80-2 3-[1-p-Tolyl-meth-(E)-ylidene]-4,5,6,7-tetrahydro-3H-isobenzofuran-1-one 

Relevant academic research and scientific papers

Carbonylation of Vinyl Halides with Carbonylcobalt

The reactions of both (E)-β-bromostyrene (E)-(1a) and its Z-isomer (Z)-(1a) with octacarbonyldicobalt in the presence of methyl iodide and calcium hydroxide at 20 deg C in dioxane-water under carbon monoxide (1 atm) gave (E)-cinnamic acid (E)-(2a) exclusively.In contrast, with (E)-1-bromo-2-phenylpropene (E)-(1b), the thermodynamically less stable (Z)-3-phenylbut-2-enoic acid (Z)-(2b) was obtained as the major product together with the (E)-isomer (E)-(2b).The carbonylation of 3-chloroprop-2-enols (7a-f) gave the corresponding furan-2(5H)-ones (8a-f) in good yield.