121032-80-2

Upstream product

• 68965-62-8 2-bromocyclohex-1-enecarboxylic acid 
• 766-97-2 4-n-methylphenylacetylene 
• 1680-73-5 2-chlorocyclohexene-1-carboxaldehyde 
• 76539-22-5 (2-chloro-1-cyclohexen-1-yl)methanol 
• 104-87-0 4-methyl-benzaldehyde 
• 121032-79-9 3-(Hydroxy-p-tolyl-methyl)-4,5,6,7-tetrahydro-3H-isobenzofuran-1-one 

Relevant academic research and scientific papers

A recyclable metal-organic framework MOF-199 catalyst in coupling and cyclization of β-bromo-α,β-unsaturated carboxylic acids with terminal alkynes leading to alkylidenefuranones

β-Bromo-α,β-unsaturated carboxylic acids react with terminal alkynes in DMF in the presence of a catalytic amount of metal-organic framework MOF-199 along with a base under microwave irradiation to afford the corresponding alkylidenefuranones in good yiel

Carbonylation of Vinyl Halides with Carbonylcobalt

The reactions of both (E)-β-bromostyrene (E)-(1a) and its Z-isomer (Z)-(1a) with octacarbonyldicobalt in the presence of methyl iodide and calcium hydroxide at 20 deg C in dioxane-water under carbon monoxide (1 atm) gave (E)-cinnamic acid (E)-(2a) exclusively.In contrast, with (E)-1-bromo-2-phenylpropene (E)-(1b), the thermodynamically less stable (Z)-3-phenylbut-2-enoic acid (Z)-(2b) was obtained as the major product together with the (E)-isomer (E)-(2b).The carbonylation of 3-chloroprop-2-enols (7a-f) gave the corresponding furan-2(5H)-ones (8a-f) in good yield.