121041-43-8

Basic information

• Product Name: 3-Pyridazinamine, 6-(2-ethoxyphenoxy)-
• Synonyms: 3-Pyridazinamine, 6-(2-ethoxyphenoxy)-
• CAS NO: 121041-43-8
• Molecular Formula: C₁₂H₁₃N₃O₂
• Molecular Weight: 231.25052
• Mol File: 121041-43-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 440.9°Cat760mmHg
• Flash Point: 220.4°C
• Appearance: /
• Density: 1.221g/cm³
• Vapor Pressure: 5.69E-08mmHg at 25°C
• Refractive Index: 1.596
• CAS DataBase Reference: 3-Pyridazinamine, 6-(2-ethoxyphenoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridazinamine, 6-(2-ethoxyphenoxy)-(121041-43-8)
• EPA Substance Registry System: 3-Pyridazinamine, 6-(2-ethoxyphenoxy)-(121041-43-8)

Safety Data

• Hazardous Substances Data: 121041-43-8(Hazardous Substances Data)

Usage

General Description

3-Pyridazinamine, 6-(2-ethoxyphenoxy)- is a chemical compound with the molecular formula C14H15N3O2. It is an aminopyridazine derivative with potential antineoplastic and antiangiogenic activities. 3-Pyridazinamine, 6-(2-ethoxyphenoxy)- has not been extensively studied, but it has shown promise in inhibiting the growth of cancer cells and blood vessel formation that supports tumor growth. It may have potential as a therapeutic agent in the treatment of cancer and other diseases related to abnormal blood vessel formation. Further research is needed to fully understand its mechanisms of action and potential medical uses.

InChI:InChI=1/C12H13N3O2/c1-2-16-9-5-3-4-6-10(9)17-12-8-7-11(13)14-15-12/h3-8H,2H2,1H3,(H2,13,14)

Upstream product

• 94-71-3 2-Ethoxyphenol 
• 5469-69-2 6-chloro-pyridazin-3-ylamine 

Downstream Products

• 128863-59-2 6-(2'-ethoxyphenoxy)-3-methoxy-2-(3-nitrophenyl)imidazo<1,2-b>pyridazine 
• 128863-60-5 6-(2'-ethoxyphenoxy)-3-methoxy-2-(4-nitrophenyl)imidazo<1,2-b>pyridazine 
• 128863-58-1 6-(2'-ethoxyphenoxy)-3-methoxy-2-(4-methoxyphenyl)imidazo<1,2-b>pyridazine 
• 128863-70-7 3-ethoxy-6-(2'-ethoxyphenoxy)-2-(4-fluorophenyl)imidazo<1,2-b>pyridazine 
• 128863-61-6 2-(3'-aminophenyl)-6-(2-ethoxyphenoxy)-3-methoxyimidazo<1,2-b>pyridazine 
• 128863-56-9 6-(2'-ethoxyphenoxy)-2-(3-fluorophenyl)-3-methoxyimidazo<1,2-b>pyridazine 
• 128863-54-7 6-(2'-ethoxyphenoxy)-3-methoxy-2-(3-methylphenyl)imidazo<1,2-b>pyridazine 
• 128863-69-4 3-ethoxy-6-(2'-ethoxyphenoxy)-2-phenylimidazo<1,2-b>pyridazine 
• 128863-57-0 6-(2'-ethoxyphenoxy)-2-(4-fluorophenyl)-3-methoxyimidazo<1,2-b>pyridazine 
• 128863-62-7 2-(4'-aminophenyl)-6-(2-ethoxyphenoxy)-3-methoxyimidazo<1,2-b>pyridazine 
• 128863-55-8 6-(2'-ethoxyphenoxy)-3-methoxy-2-(4-methylphenyl)imidazo<1,2-b>pyridazine 
• 121040-60-6 6-(2'-ethoxyphenoxy)-3-methoxy-2-phenylimidazo<1,2-b>pyridazine 

Relevant articles and documents

Imidazopyridazines. VI. Syntheses and Central Nervous System Activities of Some 6-(Alkoxy- and methylthio-phenoxy and methoxybenzylthio)-3-methoxy-2-phenyl(substituted phenyl and pyridinyl)imidazopyridazines

Series of 6-(alkoxy- and methylthio-phenoxy)-2-phenyl(substituted phenyl and pyridinyl)imidazopyridazines and 3-methoxy-6-(methoxybenzylthio)-2-phenyl(substituted phenyl and pyridinyl)imidazopyridazines have been prepared and subsesquently tested for their ability to inhibit GABA-stimulated 3H-diazepam binding to rat brain plasma membranes.The 6-(alkoxy- and methylthio-phenoxy) and 6-(methoxybenzylthio) compounds were much more effective in the displacement studies than the parent 6-phenoxy or 6-benzylthio compounds respectively.3-Methoxy-6-(2'-methoxyphenoxy)-2-phenylimidazopyridazine (GBLD-167, IC50 70 nM) was 16 times more effective than its 3-methoxy-6-phenoxy analogue (GBLD-214, IC50 1120 nM) and the 3-methoxy-6-(2'-methoxybenzylthio)-2-phenyl compound (GBLD-163, IC50 9 nM) was two and a half times more active than its 6-benzylthio-3-methoxy analogue (GBLD-137, IC50 22nM).The most active member of the 6-phenoxy series was the 2-(4'-fluorophenyl)-3-methoxy-6-(2''-methoxyphenoxy) compound (GBLD-255, IC50 30nM) and, within the 6-benzylthio series, the 2-(4'-fluorophenyl, 3'-aminophenyl, and pyridin-3'-yl)-3-methoxy-6-(3''-methoxybenzylthio) compounds (GBLD-233, 301 and 296) all gave IC50 5nM.A Hansch-type analysis of the results for these two closely related series of compounds indicates that electron-donating substituents in 2-(para substituted phenyl) derivatives favour binding, but bulky substituents hinder this effect.