121060-52-4Relevant articles and documents
Synthesis of Imidazo[2,1-b]thiazoles via Copper-Catalyzed A3-Coupling in Batch and Continuous Flow
Rassokhina, Irina V.,Tikhonova, Tatyana A.,Kobylskoy, Sergey G.,Babkin, Igor Yu.,Shirinian, Valerii Z.,Gevorgyan, Vladimir,Zavarzin, Igor V.,Volkova, Yulia A.
, p. 9682 - 9692 (2017/09/23)
A straightforward method for the synthesis of functionalized imidazo[2,1-b]thiazoles starting from benzaldehydes, 2-aminothiazoles, and alkynes under copper(I,II) catalysis was developed. The protocol allows the construction of a variety of aryl-substituted imidazo[2,1-b]benzothiazoles, -[2,1-b]thiazoles, and -[2,1-b][1,3,4]thiadiazoles. The reactions were easy to perform affording most of the desired products in 33-93% yields. The intensification of the process in a continuous-flow reactor increases the products' yields up to quantitative.