121065-97-2

Basic information

• Product Name: 3,5-DIOXO-2-[3-(TRIFLUOROMETHYL)PHENYL]-2,3,4,5-TETRAHYDRO-1,2,4-TRIAZINE-6-CARBONITRILE
• Synonyms: 3,5-DIOXO-2,3,4,5-TETRAHYDRO-2-[(3-TRIFLUOROMETHYL)PHENYL]-1,2,4-TRIAZINE-6-CARBONITRILE;3,5-DIOXO-2-[3-(TRIFLUOROMETHYL)PHENYL]-2,3,4,5-TETRAHYDRO-1,2,4-TRIAZINE-6-CARBONITRILE;6-CYANO-2,3,4,5-TETRAHYDRO-2-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-TRIAZIN-3,5-DIONE;3,5-Dioxo-2,3,4,5-tetrahydro-2-[3-(trifluoromethyl)phenyl]-1,2,4-triazine-6-carbonitrile 97%;3,5-Dioxo-2,3,4,5-tetrahydro-2-[3-(trifluoromethyl)phenyl]-1,2,4-triazine-6-carbonitrile97%
• CAS NO: 121065-97-2
• Molecular Formula: C₁₁H₅F₃N₄O₂
• Molecular Weight: 282.18
• Mol File: 121065-97-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: 173-175°C
• Appearance: /
• CAS DataBase Reference: 3,5-DIOXO-2-[3-(TRIFLUOROMETHYL)PHENYL]-2,3,4,5-TETRAHYDRO-1,2,4-TRIAZINE-6-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DIOXO-2-[3-(TRIFLUOROMETHYL)PHENYL]-2,3,4,5-TETRAHYDRO-1,2,4-TRIAZINE-6-CARBONITRILE(121065-97-2)
• EPA Substance Registry System: 3,5-DIOXO-2-[3-(TRIFLUOROMETHYL)PHENYL]-2,3,4,5-TETRAHYDRO-1,2,4-TRIAZINE-6-CARBONITRILE(121065-97-2)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 121065-97-2(Hazardous Substances Data)

Upstream product

• 118806-30-7 C₁₃H₁₁F₃N₄O₃ 
• 98-16-8 3-trifluoromethylaniline 

Downstream Products

• 1221858-75-8 C₁₈H₁₈F₃N₅O₂ 
• 1221858-73-6 C₁₉H₂₀F₃N₅O₂ 
• 1221858-59-8 C₁₅H₁₃F₃N₄O₂ 
• 66707-05-9 4-methyl-3,5-dioxo-2-(3-(trifluoromethyl)phenyl)-2,3,4,5-tetrahydro-1,2, 4-triazine-6-carbonitrile 
• 1021988-94-2 C₁₃H₉F₃N₄O₂ 
• 1221858-77-0 C₁₅H₁₄F₃N₅O₂ 
• 1221858-63-4 C₁₆H₁₃F₃N₄O₂ 
• 1221858-65-6 C₁₇H₉F₃N₄O₂ 
• 1221858-71-4 C₁₆H₁₆F₃N₅O₂ 
• 1221858-67-8 C₁₈H₁₁F₃N₄O₂ 
• 1221858-69-0 C₁₉H₁₃F₃N₄O₂ 
• 1221858-79-2 C₁₈H₁₈F₃N₅O₃ 

Relevant articles and documents

Synthesis and biological evaluation of 4-(2-fluorophenoxy)-3,3′-bipyridine derivatives as potential c-met inhibitors

Six series of novel 4-(2-fluorophenoxy)-3,3′-bipyridine derivatives conjugated with aza-aryl formamide/amine scaffords were designed and synthesized through a structure-based molecular hybridization approach. The target compounds were evaluated for c-Met kinase inhibitory activities and cytotoxicity against four cancer cell lines (HT-29, A549, MKN-45 and MDA-MB-231) in vitro. Most compounds exhibited moderate to excellent potency, and the most promising candidate 26c (c-Met kinase IC50 = 8.2 nM) showed a 4.7-fold increase in cytotoxicity against c-Met-addicted MKN-45 cell line in vitro (IC50 = 3 nM), superior to that of Foretinib (IC50 = 23 nM). The preliminary structure-activity relationship indicated that a 1H-benzo [e] [1,3,4]thiadiazine-3-carboxamide-4,4-dioxide moiety as linker contributed to the antitumor potency.