1221858-71-4Relevant articles and documents
Dioxo-triazines as a novel series of cathepsin K inhibitors
Rankovic, Zoran,Cai, Jiaqiang,Fradera, Xavier,Dempster, Maureen,Mistry, Ashvin,Mitchell, Ann,Long, Clive,Hamilton, Emma,King, Angela,Boucharens, Sylviane,Jamieson, Craig,Gillespie, Jonathan,Cumming, Iain,Uitdehaag, Joost,Zeeland, Mario van
scheme or table, p. 1488 - 1490 (2010/06/14)
A novel dioxo-triazine series of cathepsin K inhibitors was identified from HTS. A rapid exploratory programme led to the discovery of potent and selective cathepsin K inhibitors, typified by compound 24 which displayed IC50 values of 17 nM against catK and >10,000 nM in catL, catB and catS assays.
