121077-50-7Relevant academic research and scientific papers
Palladium catalyzed cross-coupling reaction of functional organozinc reagents with (2E,4E)- and (2E,4Z)-5-bromopenta-2,4-dienals: Easy access to functional conjugated dienic aldehydes
Vicart, Nicolas,Saboukoulou, Gerard-Simplice,Ramondenc, Yvan,Ple, Gerard
, p. 1509 - 1521 (2003)
Functional zinc reagents can be applied to palladium catalyzed cross-coupling reaction with (2E,4E)- and (2E,4Z)-5-bromopenta-2,4-dienal. The corresponding functional dienic aldehydes were obtained in goods yields. From the (2E,4E) isomer, the (2E,4E) dienals were isolated as single isomer according to a total stereoselective reaction. But, from the (2E,4Z) isomer the coupling reaction has lead to a mixture of (2E,4E) and (2E,4Z) isomers. A mechanism for the loss of stereoselectivity in the last case is proposed.
Palladium-catalysed atom-economical synthesis of conjugated dienals from terminal acetylenes and acrolein
Hearne, Zo?,Li, Chao-Jun
, p. 6136 - 6139 (2017/07/10)
Conjugated (E,E)-dienals are versatile synthetic intermediates owing to their trifunctional, electrophilic nature and the prevalence of the (E,E)-diene in a wide range of functional molecules. It is shown herein that (E,E)-dienals can be readily prepared
