121089-87-0

Upstream product

• 6275-29-2 N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide 
• 103-80-0 phenylacetyl chloride 
• 103-82-2 phenylacetic acid 
• 112970-37-3 2-acetyl-1-benzylidene-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline 
• 4876-02-2 N-(3,4-dimethoxyphenethyl)-phenyl acetamide 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 4876-00-0 1-benzyl-6,7-dimethoxy-3,4-dihydro-isoquinoline 

Downstream Products

• 20226-04-4 1-benzyl-6,7-dimethoxy-3,4-dihydroisoquinoline-hydrochloride 
• 340829-04-1 N-(2-(1-hydroxy-2-phenylethyl)-4,5-dimethoxyphenethyl)acetamide 
• 204002-24-4 7,8-Dimethoxy-1-methyl-5-((E)-styryl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid ethyl ester 
• 204002-21-1 N-{2-[4,5-Dimethoxy-2-((E)-styryl)-phenyl]-ethyl}-acetamide 
• 204002-23-3 7,8-Dimethoxy-1-methyl-5-((E)-styryl)-1,2,3,4-tetrahydro-isoquinoline 
• 340829-09-6 7,8-Dimethoxy-1-methyl-5-((E)-styryl)-3,4-dihydro-isoquinoline 
• 2129-60-4 2-acetyl-1-benzylidene-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline 

Relevant academic research and scientific papers

Synthesis and contractile activity of substituted 1,2,3,4- tetrahydroisoquinolines

A series of different 1-monosubstituted and 1,1-disubstituted 1,2,3,4-tetrahydroisoquinolines was synthesized in high yields from different ketoamides. We have developed a convenient method for the synthesis of disubstituted derivatives by interaction of

Photochemically induced cyclization of N-[2-(o-styryl)phenylethyl]acetamides and 5-styryl-1-methyl-1,2,3,4-tetrahydroisoquinolines: New total syntheses of 1-methyl-1,2,3,4-tetrahydronaphtho[2,1-f]isoquinolines

Two new total syntheses of 1-methyl-1,2,3,4-dihydronaphtho[1,2-f]isoquinolines are based on photochemically induced cyclization of N-{2-[(E)-2-phenyl-1-etheynyl]phenylethyl]}acetamides or 1-methyl-5-[(E)-2-phenyl-1-ethenyl]-1,2,3,4-tetrahydroisoquinolines.

First total synthesis of 1,2,3,4-tetrahydronaphtho[2,1-f]isoquinolines

Here we describe the first total synthesis of 1,2,3,4-tetrahydronaphtho[2,1-f]isoquinolines (7) from N-acyl-o-styrylphenylethylamines 3. It proceeds by the Bischler-Napieralski reaction to form the isoquinoline unit and photocyclization of the resulting 5-styrylisoquinolines.

Synthesis of isoquinolines from 2-phenylethylamines, amides, nitriles and carboxylic acids in polyphosphoric acid

A convenient one pot synthesis of 1-, 1.3-substituted 3,4-dihydroisoquinolines 5 enamines 10 and 3-oxo-2,3-dihydroisoquinolines 18 as well as of enamides 22 of isoquinoline from 2-phenyl-, 1,2-diphenylethylamines, phenylacetamides, phenylacetonitriles, N-acylphenylethylamines and carboxylic acids in nonaqueous media has been accomplished.

STUDIES ON FRIEDEL-CRAFTS ACYLATION OF N-ACETYLHOMOVERATRYLAMINE AND PREPARATION OF 1-SUBSTITUTED 3,4-DIHYDRO-6,7-DIMETHOXYISOQUINOLINES

Friedel-Crafts acylation of N-acetylhomoveratrylamine in a molar ratio of 1:2:3 of 1, AlCl3 and the appropriate acid chloride using nitrobenzene as solvent gave the corresponding 2-acyl derivatives 2a-j in good yields.Subsequent treatment of 2 in boiling