4876-00-0

Basic information

• Product Name: Isoquinoline, 3,4-dihydro-6,7-dimethoxy-1-(phenylmethyl)-
• CAS NO: 4876-00-0
• Molecular Formula: C18H19NO2
• Molecular Weight: 281.354
• Mol File: 4876-00-0.mol
• Article Data: 22

Chemical Properties

• CAS DataBase Reference: Isoquinoline, 3,4-dihydro-6,7-dimethoxy-1-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Isoquinoline, 3,4-dihydro-6,7-dimethoxy-1-(phenylmethyl)-(4876-00-0)
• EPA Substance Registry System: Isoquinoline, 3,4-dihydro-6,7-dimethoxy-1-(phenylmethyl)-(4876-00-0)

Safety Data

• Hazardous Substances Data: 4876-00-0(Hazardous Substances Data)

Upstream product

• 4876-02-2 N-(3,4-dimethoxyphenethyl)-phenyl acetamide 
• 14301-36-1 N-[2-(3,4-dimethoxyphenyl)ethyl]formamide 
• 93-97-0 benzoic acid anhydride 
• 103-80-0 phenylacetyl chloride 
• 6125-24-2 2-Phenylnitroethane 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 101-97-3 Ethyl 2-phenylethanoate 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 39220-86-5 2-nitro-1-(3,4-dimethoxyphenyl)ethanol 
• 103-82-2 phenylacetic acid 
• 77199-00-9 N-(2-<3,4-dimethoxyphenyl>-ethyl)-benzene-sulfonylamide 
• 894419-48-8 N-[2-(4,5-dimethoxy-2-phenylacetylphenyl)ethyl]formamide 

Downstream Products

• 1491132-46-7 11B-benzyl-9,10-dimethoxy-2-methyl-7,11b-dihydro-4H,6H-[1,3]oxazino[2,3-a]isoquinolin-4-one 
• 1491132-44-5 9,10-dimethoxy-2-methyl-1-phenyl-6,7-dihydro-4H-pyrido[2,1-a]isoquinolin-4-one 

Relevant articles and documents

Enhancement of the carbamate activation rate enabled syntheses of tetracyclic benzolactams: 8-oxoberbines and their 5- And 7-membered C-ring homologues

A route to the direct amidation of aromatic-ring-tetheredN-carbamoyl tetrahydroisoquinoline substrates was developed. This route enabled general access to 8-oxoberberines and their 5- and 7- membered C-ring homologues. It overcomes the undesired tandem side-reactions that result in the destruction of the isoquinoline backbone, which inevitably occurred under our previously reported superacidic carbamate activation method.

Copper(ii)-catalyzed and acid-promoted highly regioselective oxidation of tautomerizable C(sp3)-H bonds adjacent to 3,4-dihydroisoquinolines using air (O2) as a clean oxidant

A mild, efficient and eco-friendly method for the oxidation of 1-Bn-DHIQs to 1-Bz-DHIQs without concomitant excessive oxidation of 1-Bz-DHIQs to 1-Bz-IQs is very important for the syntheses of 1-Bz-DHIQ alkaloids and analogues. In this article, we developed a novel Cu(ii)-catalyzed and acid-promoted highly regioselective oxidation of tautomerizable C(sp3)-H bonds adjacent to the C-1 positions of various 1-Bn-DHIQs. It was observed that when 0.2 equiv. of Cu(OAc)2·2H2O was used as the catalyst, 3.0 equiv. of AcOH was used as the additive and air (O2) was used as a clean oxidant, various 1-Bn-DHIQs could be efficiently oxidized to corresponding 1-Bz-DHIQs at 25 °C in DMSO. Especially, almost no concomitant excessive oxidation of 1-Bz-DHIQs to 1-Bz-IQs was observed during the above reaction. In addition, this method was successfully applied in the first total synthesis of the alkaloid canelillinoxine.

Synthesis of N-Heterocycles by Reductive Cyclization of Nitroalkenes Using Molybdenum Hexacarbonyl as Carbon Monoxide Surrogate

The development of a method that uses molybdenum hexacarbonyl [Mo(CO)6] as carbon monoxide (CO) surrogate for the palladium-catalyzed reductive cyclization of nitroalkenes into indoles or thienopyrroles is reported. Several types of nitroalkenes could be transformed into the desired products in excellent yields and in most cases with complete regioselectivities and higher yields than those previously reported with palladium/CO system.