1211-19-4

Usage

Uses

Used in Dye and Pigment Industry:
BenzaMide, 2-(phenylaMino)is used as a dye intermediate for the manufacturing of various dyes and pigments. Its chemical structure allows it to contribute to the color properties and stability of these products.
Used in Pharmaceutical Industry:
BenzaMide, 2-(phenylaMino)is used as a building block in the synthesis of pharmaceuticals. Its unique structure can be incorporated into drug molecules to enhance their therapeutic properties or improve their pharmacokinetic profiles.
Used in Chemical Research:
BenzaMide, 2-(phenylaMino)serves as a valuable compound in chemical research, particularly in the study of benzamide derivatives and their potential applications in various fields. Its synthesis and modification can provide insights into the development of new chemical entities with diverse functionalities.

InChI:InChI=1/C13H12N2O/c14-13(16)11-8-4-5-9-12(11)15-10-6-2-1-3-7-10/h1-9,15H,(H2,14,16)

Upstream product

• 35708-19-1 Methyl N-phenylanthranilate 
• 20877-86-5 N-phenyl isatoic anhydride 
• 91-40-7 2-(phenylamino)benzoic acid 
• 108-86-1 bromobenzene 
• 28144-70-9 anthranilic acid amide 
• 66003-76-7 Diphenyliodonium triflate 
• 98-80-6 phenylboronic acid 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 3930-83-4 o-iodobenzamide 
• 62-53-3 aniline 
• 57623-73-1 2-(phenylamino)benzoyl chloride 

Downstream Products

• 66491-82-5 2-cyclopropyl-1-phenyl-4(1H)-quinazolinone 
• 66491-84-7 2-(ethoxycarbonyl)-1-phenyl-4(1H)-quinazolinone 
• 70344-46-6 2-isopropyl-1-phenyl-4(1H)-quinazolinone 
• 75065-08-6 2-(β-chloroethyl)-1-phenyl-4(1H)-quinazolinone 
• 95216-36-7 2-Isobutyl-1-phenyl-1H-quinazolin-4-one 
• 71567-82-3 2-Cyclohexyl-1-phenyl-1H-quinazolin-4-one 
• 95216-37-8 1-phenyl-2-(trifluoromethyl)-4(1H)-quinazolinone 
• 75065-09-7 2-(γ-chloropropyl)-1-phenyl-4(1H)-quinazolinone 
• 17583-00-5 2-phenylaminobenzonitrile 
• 182679-35-2 2-(4-Oxo-1-phenyl-1,4-dihydro-quinazolin-2-ylmethyl)-isoindole-1,3-dione 
• 1023310-06-6 2-ethyl-1-phenyl-1H-quinazolin-4-one 
• 1023310-10-2 C₂₀H₂₃N₃O 
• 14813-85-5 1-phenyl-1,3-dihydrobenzoimidazol-2-one 
• 66478-79-3 2-chloromethyl-1-phenyl-4(1H)-quinazolinone 

Relevant academic research and scientific papers

A facile synthesis of (Z)-1, 6-disubstituted-7H-benzo[b][1,5]diazonin-7-one derivatives via arylation-allylation-RCM pathway of anthranilamide and isatoic anhydride

A facile and efficient method has been developed for the synthesis of (Z)-6-allyl-1-phenyl-1,2,5,6-tetrahydro-7H-benzo[b][1,5]diazonin-7-one and (Z)-1,6-diphenyl-1,2,5,6-tetrahydro-7H-benzo[b][1,5]diazonin-7-one from anthranilamide via N-arylation/N-allylation and from isatoic anhydride via ring opening/N-arylation/N-allylation followed by ring closing metathesis using Grubbs-II catalyst as a key step. Grubbs-II catalyst was found to be superior over Grubbs-I catalyst in terms of reaction time and yield of the product, and the routes developed were suitable to synthesize benzo fused nine membered nitrogen heterocycles. The requirement of diallylated substrates with protected amine and amide nitrogen is suitable for RCM has been established for the synthesis of diazoninone derivatives.

Amidation of polyaromatic carboxylic acids in aqueous medium

The amidation of polyaromatic carboxylic acids, such as 4- biphenylcarboxylic acid, 4-biphenylacetic acid, 4-carboxy-4'-hydroxybiphenyl, and N-phenylanthranilic acid, was satisfactorily carried out to give the corresponding amides using a wild-type bacter

Unravelling the photophysics of triphenylamine and diphenylamine dyes: A comprehensive investigation with: Ortho -, meta - And para -amido substituted derivatives

The triphenylamine (TPA) and diphenylamine (DPA) derivatives constitute an important class of dyes that are suitable for many fluorescence-based applications. This study provides a thorough understanding about the photophysics of ortho-, meta- and para-am

Effects of amino acids on the amidation of polyaromatic carboxylic acids by Bacillus cereus.

The soil bacterium Bacillus cereus Tim-r01 efficiently transformed polyaromatic carboxylic acids (PACA) such as 4-biphenylcarboxylic acid (4-BPCA), 4-biphenylacetic acid, and 4-phenoxybenzoic acid into their corresponding amides. The amidation activity was expressed at 37 degrees C (pH 7-8) in the presence of grown cells in nutrients under an aerobic atmosphere. Other strains of B. cereus, IFO 3001 and IAM 1229, also gave the amide from 4-BPCA. In phosphate-buffered saline (PBS), the addition of normal amino acids was essential, while sulfur-containing amino acids such as methionine and cysteine drastically inhibited the amidation. Tracer experiments using N-15-isoleucine and N-15-alanine showed that the nitrogen atom of the amide came from an amino group of amino acids but not from ammonia or alkylamines.

Synthesis, biological screening, and molecular docking of quinazolinone and quinazolinethione as phosphodiesterase 7 inhibitors

N-Substituted isatoic anhydrides were used as starting materials for the synthesis of compounds 5–16 through alkali hydrolysis, Schiff base reactions, and oxidation. Compounds 18–23 were obtained by thionation of their oxo isosteres using Lawesson's reage

An Efficient Ni/Pd Catalyzed Chemoselective Synthesis of 1,3,2-Benzodiazaborininones from Boronic Acids and Anthranilamides

An efficient Ni/Pd catalyzed chemoselective synthesis of 1,3,2-benzodiazaborininones from boronic acids and anthranilamide has been developed. This protocol allows for the rapid and straightforward access to a wide range of 1,3,2-benzodiazaborininones at roomtemperature with excellent functional group tolerance. (Figure presented.).

Synthesis of blue-red emissive amido-substituted di(het)aryl and tri(het)aryl amine derivatives via chemoselective N-mono and N,N-diarylation of (het) aryl amino amides using benzyne/arynes

Herein, via chemoselective N-mono and N,N-diarylation of an aryl/hetaryl amino amide reaction using benzyne or arynes, an amide-substituted triaryl amine derivative and diaryl amine derivatives were afforded. The scope and limitation of the present study have been studied. The products thus obtained were synthetically transformed to highly functionalized biphenyl bridged heterocycles via Suzuki coupling and condensation with 4,4′-biphenyl dialdehyde. Evaluation of the photophysical properties has revealed that the triaryl amine derivatives are blue emissive with high quantum yields, whereas the heterocyclic triaryl amine derivatives are blue-red emissive. The benzofuran-derived compound 4i was found to be blue emissive with high quantum yield, whereas the pyridine-derived compound 5j was found to be red emissive with low quantum yield.

Chemoselective: N -arylation of aminobenzamides via copper catalysed Chan-Evans-Lam reactions

Chemoselective N-arylation of unprotected aminobenzamides was achieved via Cu-catalysed Chan-Evans-Lam cross-coupling with aryl boronic acids for the first time. Simple copper catalysts enable the selective arylation of amino groups in ortho/meta/para-aminobenzamides under open-flask conditions. The reactions were scalable and compatible with a wide range of functional groups.

Preparation method for arylamine benzamides compounds and N-aryl-arylamine benzamides compounds

The invention provides a preparation method for arylamine benzamides compounds and N-aryl-arylamine benzamides compounds and belongs to the technical field of refining. According to the method provided by the invention, carbon nitrogen coupling reaction is performed by using arylboronic acid (or borate) as an aryl reagent under a copper-catalyzed condition, the reaction is performed at 10-35 DEG C and the selective arylation of aminophenamide is realized. Compared with the present Buchwald-Hartwig carbon nitrogen coupling reaction under palladium-catalyzed condition, the carbon nitrogen coupling reaction has the advantages that the catalyst is low in cost and low in toxicity, the raw materials are simple, easily acquired, stable and low-toxicity, the reaction temperature is greatly reduced, inert gas atmosphere protection is not required, the stirring reaction can be directly performed in an opening reaction flask under a room temperature condition, the condition is mild and the operation is easy, aniline locally has high-selective arylation reaction, the reaction yield is high, the product is easily purified and the atom economy is high.

Selective C-N coupling reaction of diaryliodonium salts and dinucleophiles

N-Aryl-α-amino amides including their chiral isomers have demonstrated important applications as pharmaceutical drugs; however, to date, a one-step synthetic route for them still remains to be developed. Herein, an efficient ligand-free copper-catalyzed selective C-N coupling reaction of diaryliodonium salts and dinucleophiles under mild conditions was realized. Diaryliodonium salts prefer to react with dinucleophiles at the site of stronger alkalic amino groups. Thus, a general aliphatic amino-selective N-arylation of α-amino amides was disclosed. Additionally, copper-catalyzed N-arylation of diaryliodonium salts afforded the same products as obtained via palladium-catalyzed reactions of aryl halides.