1211025-52-3Relevant academic research and scientific papers
NOVEL SUBSTITUTED N'-HYDROXYCARBAMIMIDOYL-1,2,5-OXADIAZOLE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS
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Page/Page column 33; 40, (2018/10/25)
Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof. Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.
Energetic materials containing fluorine. Design, synthesis and testing of furazan-containing energetic materials bearing a pentafluorosulfanyl group
Martinez, Henry,Zheng, Zhaoyun,Dolbier Jr., William R.
, p. 112 - 122,11 (2020/08/20)
The advantageous impact of a pentafluorosulfanyl substituent on the properties of furazan-containing energetic materials was demonstrated by the synthesis and study of the energetic properties of ten new compounds. The thermal stability of these compounds was evaluated by DSC and TGA, whereas densities, heats of formation, pressures of detonation and speeds of detonation were obtained computationally. On the basis of these data, it was concluded that the combination of the SF5 substituent with the furazan ring led to materials of higher density and predicted detonation properties than other known furazans or SF5-containing materials. In addition, the synthetic studies provided insight regarding the electron-withdrawing nature of the furazan ring, in particular its effect on the basicity and nucleophilic reactivity of amino furazans.
