156463-85-3

Usage

Chemical Properties

White crystal

Upstream product

• 540-61-4 2-aminoacetonitrile 
• 13300-88-4 4-amino-1,2,5-oxadiazole-3-carboxylic acid amide 
• 1211025-52-3 4-amino-N’-hydroxy-1,2,5-oxadiazole-3-carboximidamide 
• 13490-32-9 4-amino-N-hydroxy-furazan-3-carboxamidine 
• 1211025-52-3 4-amino-N-hydroxyfurazan-3-carboxamidine 
• 13490-32-9 amidoxime of 4-aminofurazan-3-carboxylic acid 

Downstream Products

• 13490-32-9 4-amino-N-hydroxy-furazan-3-carboxamidine 
• 167281-92-7 4-aminofurazan-3-carboxamidrazone 
• 696631-99-9 methyl 7-amino-5-methyl[1,2,5]oxadiazolo[3,4-b]pyridine-6-carboxylate 
• 246048-63-5 methyl 4-amino-1,2,5-oxadiazolyl-3-carbimidate 
• 159014-14-9 4-nitro-1,2,5-oxadiazole-3-carbonitrile 
• 1279684-99-9 2-chloro-3-[5-(cyanomethyl)-4,5-dihydro-1,2-oxazol-3-yl]-N-(4-cyano-1,2,5-oxadiazol-3-yl)-4-(ethylsulfonyl)benzamide 
• 167281-96-1 3-amino-4-(1,2,3,4-tetrazol-5-yl)furazan 

Relevant academic research and scientific papers

Synthesis and properties of 3-azido-4-(2H-tetrazol-5-yl)furazan

[Figure not available: see fulltext.] We describe an effective scheme for the synthesis of a new energetic compound – 3-azido-4-(2H-tetrazol-5-yl)furazan from 4-amino-N'-hydroxyfurazan-3-carboximidamide. The structure of 3-azido-4-(2H-tetrazol-5-yl)furazan was proved by 1Н and 13С NMR spectroscopy, mass spectrometry, and X-ray structural analysis. 3-Azido-4-(2H-tetrazol-5-yl)furazan crystallized in monoclinic syngony, space group Р21/n, monocrystal density d 1.953 g·cm–3 (100 K). According to differential scanning calorimetry data, 3-azido-4-(2Htetrazol-5-yl)furazan melts at 103.3°С, while the maximum of thermal decomposition exotherm was observed at 185.6°С. The sensitivity of 3-azido-4-(2H-tetrazol-5-yl)furazan to impact (2 kg, 25 cm, 36% explosion frequency) and to friction (1450 kg·cm–3 lower limit) was at the level of pentaerythritol tetranitrate. The salts of 3-azido-4-(2H-tetrazol-5-yl)furazan with ammonia and guanylurea were also obtained and characterized.

Nonmetallic Pentazole Salts Based on Furazan or 4-Nitropyrazole for Enhancing Density and Stability

In this work, three novel nonmetallic pentazole salts (6-8) based on furazan or 4-nitropyrazole were synthesized. Some coplanar groups were introduced into the compounds to improve the planarity of the crystal packing. 4-Amino-1,2,5-oxadiazole-3-carbohydrazonamide pentazolate (6), 5-(4-amino-1,2,5-oxadiazol-3-yl)-4H-1,2,4-triazole-3,4-diamine pentazolate (7), and 5,5′-(4-nitro-1H-pyrazole-3,5-diyl)-bis(4H-1,2,4-triazole-3,4-diamine) pentazolate (8) all show more stable π-πstacking and exhibit superior thermal stability (110.5-116.4 °C) than most other reported nonmetallic pentazole salts (Tonset: 80-110 °C), and compound 8 has the highest crystal density (1.722 g·cm-3/173 K) of nonmetallic pentazole salts to date. All salts have been thoroughly characterized by NMR (1H and 13C) spectroscopy, infrared (IR), Roman (RA), and elemental analysis. The decomposition temperature of all salts displays more than 110 °C, which is measured by differential scanning calorimetry (DSC). These compounds all shows low sensitivity (IS > 35 J, FS > 360 N) measured by standard BAM methods. Glycidyl azide polymer (GAP) based propellant formula with the addition of salt 6 or 7 shows a higher specific impulse (6, Isp = 262.1 s; 7, Isp = 263.9 s) than that of RDX (Isp = 259.0 s). This study can provide a new crystal engineering way for the synthesis of pentazole salt to solve the problem of low density and poor stability.

PROCESS FOR MANUFACTURING ALKYL 7-AMINO-5-METHYL- [1,2,5]OXADIAZOLO[3,4-B]PYRIDINE-CARBOXYLATE

This invention relates to a novel process for making alkyl 7-amino-5-methyl-[1,2,5]-oxadiazolo[3,4-b]pyridine-carboxylate.

Synthesis, crystal structure, and thermal properties of Ni(NH3)4(AFT)2

Ni(NH3)4(AFT)2 [NiC6H16N18O2, AFT = 4-amino-3-(5-tetrazolate)furazan] is synthesized and characterized by elemental analysis and Fourier-transform infrared spectroscopy for the first time. X-ray diffraction measurements are used to determine the crystal structure of compound 1. The results demonstrate that compound 1 crystallized in the orthorhombic crystal system. The nickel(II) ion is six-coordinated by N atoms from two AFT-ligands and four NH3 molecules. Its thermal properties are investigated by differential scanning calorimetry and thermogravimetry-derivative thermogravimetry methods, with the results demonstrating that the differential scanning calorimetry curve exhibits two endothermic and one exothermic processes. The endothermic processes are in the range of 130–510 °C with a peak temperature of 188 °C. The temperature from 230 to 400 °C is the exothermic process in which the peak temperature is 314.58 °C. In addition, Kissinger’s and Ozawa-Doyle’s methods are used for calculating the non-isothermal kinetics parameters. Moreover, the apparent activation energy (E), safety, and thermal stability parameters (TSADT, TTIT, Tb) for Ni(NH3)4(AFT)2 are calculated. In addition, the calculated thermodynamic functions (?S≠, ?H≠, and ?G≠) for the exothermic decomposition process of Ni(NH3)4(AFT)2 are 55.07 J mol?1 K?1, 196.18 kJ mol?1, and 164.90 kJ mol?1, respectively.

Benzimidazole bifurazan series compounds and synthesis method thereof

The invention provides benzimidazole bifurazan series compounds and a synthesis method thereof. The molecular structure of the compounds is represented by a formula I, wherein R1 is selected from hydrogen, halogen, trifluoromethyl, nitryl, amino, sulfo, methyl, tert-butyl, methoxyl, carboxyl, ethoxyformyl or benzoyl; R2 is selected from hydrogen or fluorine. On the basis, the invention discloses an efficient method for preparing the series of compounds. The preparation method comprises the steps: synthesizing an intermediate 4-amino-1,2,5-oxadiazole-3-methoxyamidine by taking malononitrile asa starting raw material, carrying out a reaction on the intermediate with o-phenylenediamine or a substitute thereof under a heating reflux condition by taking acetic acid as a solvent, cooling, adding water, stirring to separate out a solid after the reaction is finished, and carrying out suction filtration, washing, drying and the like to obtain a final product. According to the method, a pure product can be obtained without recrystallization, column chromatography separation and other steps, the method is simple, rapid and practical, and the yield can generally reach 80% or above.

Chromone-containing benzimidazole bifurazan compound with Cy-FBP/SBPase inhibition effect and preparation method of chromone-containing benzimidazole bifurazan compound

The invention provides a chromone-containing benzimidazole bifurazan compound with a Cy-FBP/SBPase inhibition effect and a preparation method of the chromone-containing benzimidazole bifurazan compound. The molecular structure of the compound is shown as

A novel energetic framework combining the advantages of furazan and triazole: A design for high-performance insensitive explosives

A series of tetracyclic furazan-triazole compounds have been synthesized and fully characterized. The predicted detonation performance and tested mechanical sensitivities showed their high-energy performance and insensitive features. Quantum chemical calculations and crystal structure analysis were applied to study the intrinsic structure-property relationship among these compounds. In addition, the detonation test shows their promising potential as secondary explosives.

Preparation method for 4-amino-3-cyan furazan

The invention discloses a preparation method for 4-amino-3-cyan furazan. The preparation method comprises the following steps: first, carrying out a reaction on 4-amino furazan-3-formamide as a raw material and N,N-dialkyl substituted formamide, a chloride agent and organic alkali to obtain an intermediate; and then carrying out a reaction on the intermediate and diluted hydrochloric acid and carrying out post-treatment to obtain the 4-amino-3-cyan furazan. The preparation method is simple, short in reaction period, free of phosphorus containing reagents and free of heavy metals. Compared withthe prior art, the preparation method is small in environmental pollution, safe to operate and low in cost.

NOVEL SUBSTITUTED N'-HYDROXYCARBAMIMIDOYL-1,2,5-OXADIAZOLE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS

Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: Formula (I). Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

A new coordination compound based on 4-amino-3-(tetrazol-5-yl)-furazan (HAFT): preparation, crystal structure, and thermal properties

The green nitrogen-rich coordination compound Cd(SCZ)2(AFT)2 (1) (AFT =4-amino-3-(5-tetrazolate)-furazan and SCZ = semicarbazide) was first synthesized and characterized by EA and Fourier Transform Infrared (FT-IR). The single crystal was cultivated and determined with X-ray diffraction. It revealed that 1 crystallizes in the monoclinic space group P21/c. A Cd2+ ion is coordinated by four N atoms and two O atoms to form a distorted octahedral structure. Among them, two nitrogen atoms are from the two AFT ions and the other four atoms are from two SCZ molecules. The thermal decomposition behavior of 1 was studied with DSC and TG-DTG methods. The apparent activation energy (E), thermal stability, and safety parameters (TSADT, TTIT, and Tb) were calculated for 1. Moreover, entropy of activation (ΔS≠), enthalpy of activation (ΔH≠), free energy of activation (ΔG≠), specific heat capacity (Cp), and impact sensitivity were also discussed in detail.