147085-13-0

Usage

Uses

Used in Pharmaceutical Synthesis:
1,2,5-Oxadiazole-3-carboximidoyl chloride, 4-amino-N-hydroxyis employed as a reagent in the synthesis of oxadiazole derivatives, which are known for their wide range of biological and pharmacological activities. These derivatives are valuable in the development of new drugs and therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, 1,2,5-Oxadiazole-3-carboximidoyl chloride, 4-amino-N-hydroxyacts as a precursor for the production of various functional groups. This makes it a crucial component in the creation of complex organic molecules and contributes to the advancement of chemical research and development.
Used in Research and Development:
Due to its reactivity and potential in forming a variety of biologically active compounds, 1,2,5-Oxadiazole-3-carboximidoyl chloride, 4-amino-N-hydroxyis also used in research and development for exploring new chemical reactions and the creation of novel compounds with potential applications in various industries.

Upstream product

• 13490-32-9 4-amino-N-hydroxy-furazan-3-carboxamidine 
• 1211025-52-3 4-amino-N’-hydroxy-1,2,5-oxadiazole-3-carboximidamide 
• 109-77-3 malononitrile 

Downstream Products

• 147085-15-2 3,6-bis(4-amino-1,2,5-oxadiazol-3-yl)-1,4,2,5-dioxadiazine 
• 296244-55-8 3,4-bis(4-amino-1,2,5-oxadiazol-3-yl)-1,2,5-oxadiazole N-oxide 
• 1169568-08-4 4-amino-N-(3-tert-butylphenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide 
• 914471-09-3 4-amino-N-(3-chloro-4-fluorophenyl)-N‘-hydroxy-1,2,5-oxadiazole-3-carboximidamide 

Relevant academic research and scientific papers

Synthesis of macrocyclic systems from 4,4'-diamino-3,3'-bi-1,2,5-oxadiazole and 3(4)-amino-4(3)-(4-amino-1,2,5-oxadiazol-3-yl)-1,2,5-oxadiazole 2-oxides

Oxidative cyclocondensation of 4,4'-diamino-3,3'-bi-1,2,5-oxadiazole and isomeric 3(4)-amino-4(3)-(4-amino-1,2,5-oxadiazol-3-yl)-1,2,5-oxadiazole 2-oxides under the action of dibro-moisocyanurate gave 12- and 18-membered macrocyclic systems containing two or three bifurazanyl or furazanylfuroxanyl moieties linked by azo bridges. The latter were oxidized into azoxy groups with Caro's acid in 20% oleum.

A rational method of synthesis and chemical properties of 5-(4-aminofurazan-3-yl)-1-hydroxytetrazole

[Figure not available: see fulltext.] A practical and scalable scheme for the synthesis of 5-(4-aminofurazan-3-yl)-1-hydroxytetrazole was developed, starting from 4-aminofurazan-3-carboxylic acid amidoxime. New methods were proposed for the synthesis of 1

Oxadiazole derivative, preparation method and applications thereof

The invention relates to an oxadiazole derivative, a preparation method and applications thereof, wherein the oxadiazole derivative has a structure represented by a formula (I), and R1, X and R2 are defined in the specification.

2, 3-dioxygenase inhibitor containing substituted amidino structure as well as preparation method and application thereof

The invention belongs to the field of drug synthesis, and relates to a 1,2,5-oxadiazole compound csubstituted amidino group as shown in a general formula (I) and pharmaceutically acceptable salts thereof, and a preparation method and medical application o

2,3-dioxygenase inhibitor containing thio four-membered ring structure as well as preparation method and application of 2, 3-dioxygenase inhibitor

The invention belongs to the field of drug synthesis, and relates to a 1,2,5-oxadiazole compound containing a thio four-membered ring shown in a general formula (I) and pharmaceutically acceptable salts thereof, and a preparation method and medical applic

Design, synthesis, and biological evaluation of 1,2,5-oxadiazole-3-carboximidamide derivatives as novel indoleamine-2,3-dioxygenase 1 inhibitors

Indoleamine 2,3-dioxygenase 1 (IDO1) is the enzyme catalyzing the oxidative metabolism of tryptophan, which accounts for cancer immunosuppression in tumor microenvironment. Several compounds targeting IDO1 have been reported and epacadostat shows strong i

Finding furoxan rings

A furoxan ring is derived from a dinitromethyl group. A plausible mechanism is proposed based on 1H, 13C and 15N NMR spectral analysis where a dinitromethyl group releases one molecule of nitric acid to form an unstable nitrile oxide and its dipole isomer which cyclize to a furoxan ring [3,4-bis(4-nitro-1,2,5-oxadizaol-3-yl)-1,2,5-oxadiazole-N-oxide (5)]. This new method of constructing a furoxan (1,2,5-oxadiazole 2-oxide) ring offers a potentially efficient way to obtain excellent energetic materials. In order to stabilize the dinitromethyl-containing precursor [3-(dinitromethyl)-4-nitro-1,2,5-oxadiazole (4)], a series of new energetic salts was synthesized and fully characterized. These materials exhibit high densities, excellent detonation properties and acceptable sensitivities. For example, the hydrazinium salt 9 has a high density of 1.92 g cm-3, a detonation velocity of 9437 m s-1 and a detonation pressure of 41.3 GPa, which approach those properties of CL-20 (ρ, 2.03 g cm-3; vD, 9406 m s-1; P, 44.6 GPa) and which are superior to those of HMX (ρ, 1.90 g cm-3; vD, 9320 m s-1; P, 39.2 GPa).

IDO inhibitor, composition, preparation method and application thereof

The invention provides a class of bridged iodinated cyclohexyl oxadiazole derivatives, and a preparation method thereof, and application of the bridged iodinated cyclohexyl oxadiazole derivatives as IDO inhibitors, and mainly relates to the technical fiel

DEUTERATED INDOLEAMINE 2,3-DIOXYGENASE INHIBITOR AND APPLICATION THEREOF

The present invention belongs to the technical field of medicine, and particularly relates to a compound represented by Formula I, a pharmaceutically acceptable salt thereof, and a stereoisomer thereof, R4, R4′, R5, R

Synthesis and in vivo antitumor evaluation of an orally active potent phosphonamidate derivative targeting IDO1/IDO2/TDO

Targeting Trp-Kyn pathways has been identified as an attractive approach for the cancer immunotherapies. In this study, a novel phosphonamidate containing compound was designed, synthesized and evaluated for its inhibitory activity against key dioxygenase