121125-08-4Relevant academic research and scientific papers
Total synthesis of the biphenomycins; III. Synthesis of biphenomycin B
Schmidt,Meyer,Leitenberger,Griesser,Lieberknecht
, p. 1025 - 1030 (2007/10/02)
The total synthesis of the cyclopeptide biphenomycin B (1b), a compound exhibiting a potent antibacterial activity against Gram-positive bacteria, is described. The non-proteinogenic amino acid (S,S)-diisotyrosine (2) was prepared by enantioselective hydrogenation of the corresponding didehydroamino acids. The 15-membered ansa ring was obtained in 85% yield within 5 minutes by ring closure of the appropriate linear pentafluorophenyl ester in the two phase system chloroform-aqueous sodium hydrogen carbonate without dilution.
