121125-11-9

Upstream product

• 1761-62-2 5-iodosalicyclaldehyde 
• 616888-59-6 2(S)-benzyloxycarbonylamino-3-(2-benzyloxy-5-iodophenyl)propionic acid (2-trimethylsilyl)ethyl ester 
• 636594-72-4 benzyl 3-[2-benzyloxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-2(S)-tert-butoxycarbonylaminopropionate 
• 121056-95-9 trimethyl 2-(tert-butoxycarbonylamino)phosphonoacetate 
• 134038-81-6 3'-<(Z)-2-(tert-Butoxycarbonylamino)-2-(methoxycarbonyl)vinyl>-4,4'-dibenzyloxy-3-(1,3-dioxan-2-yl)biphenyl 
• 145240-78-4 3-<(S)-2-(tert-Butoxycarbonylamino)-2-(benzyloxycarbonyl)ethyl>-4,4'-dibenzyloxy-3'-(1,3-dioxan-2-yl)biphenyl 
• 145240-75-1 3'-<(Z)-2-(tert-Butoxycarbonylamino)-2-carboxyvinyl>-4,4'-dibenzyloxy-3-(1,3-dioxan-2-yl)biphenyl 
• 145240-77-3 3-<(S)-2-(tert-Butoxycarbonylamino)-2-carboxyethyl>-4,4'-dibenzyloxy-3'-(1,3-dioxan-2-yl)biphenyl 
• 134038-79-2 4,4'-Dibenzyloxy-3-(1,3-dioxane-2-yl)-3'-(1,3-dithiane-2-yl)biphenyl 
• 134038-78-1 2-(2-Benzyloxy-5-iodophenyl)-1,3-dithian 
• 134038-89-4 2-benzyloxy-5-iodobenzaldehyde 
• 121125-02-8 (Z)-3-(2-Benzyloxy-5-bromo-phenyl)-2-tert-butoxycarbonylamino-acrylic acid benzyl ester 
• 121125-03-9 (E)-3-(2-Benzyloxy-5-bromo-phenyl)-2-tert-butoxycarbonylamino-acrylic acid benzyl ester 
• 121125-08-4 (E)-2-Benzyloxycarbonylamino-3-[4,4'-bis-benzyloxy-3'-((S)-2-benzyloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-biphenyl-3-yl]-acrylic acid 2-trimethylsilanyl-ethyl ester 

Downstream Products

• 134038-83-8 (S)-3-[3'-((S)-2-Amino-2-benzyloxycarbonyl-ethyl)-4,4'-bis-benzyloxy-biphenyl-3-yl]-2-benzyloxycarbonylamino-propionic acid 2-trimethylsilanyl-ethyl ester 
• 636594-74-6 2-(Trimethylsilyl)ethyl 3-[3'-(2(S)-amino-2-benzyloxycarbonylethyl)4,4'-bisbenzyloxybiphenyl-3-yl]-2(S)-benzyloxycarbonylaminopropionate hydrochloride 
• 134038-85-0 (S)-2-((2S,4R)-5-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-4-hydroxy-pentanoylamino)-3-{4,4'-bis-benzyloxy-3'-[(S)-2-benzyloxycarbonylamino-2-(2-trimethylsilanyl-ethoxycarbonyl)-ethyl]-biphenyl-3-yl}-propionic acid benzyl ester 
• 134038-84-9 C₇₃H₈₄N₄O₁₄Si 
• 145240-76-2 2(S)-benzyloxycarbonylamino-3-{4,4'-bisbenzyloxy-3'-[2(S)-benzyloxycarbonyl-2-(5-benzyloxycarbonylamino-2(S)-tert-butoxycarbonylamino-4(R)-hydroxypentanoylamino)ethyl]biphenyl-3-yl}propionic acid 
• 134038-87-2 benzyl 5,17-bisbenzyloxy-14(S)-benzyloxycarbonylamino-11(S)-(3-benzyloxycarbonylamino-2(R)-hydroxypropyl)-10,13-dioxo-9,12-diazatricyclo[14.3.1.12,6]-henicosa-1(19),2,4,6(21),16(20),17-hexaene-8(S)-carboxylate 
• 134038-86-1 benzyl 2(S)-(5-benzyloxycarbonylamino-2(S)-tert-butoxycarbonylamino-4(R)-hydroxypentanoylamino)-3-[4,4'-bisbenzyloxy-3'-(2(S)-benzyloxycarbonylamino-2-pentafluorophenyloxycarbonylethyl)biphenyl-3-yl]propionate 

Relevant academic research and scientific papers

Antibacterial amide macrocycles

The invention relates to antibacterial amide macrocycles, to methods for the production thereof, and to the use of the same for producing pharmaceuticals for the treatment and/or prophylaxis of illness, especially bacterial infections.

Total synthesis of the biphenomycins; III. Synthesis of biphenomycin B

The total synthesis of the cyclopeptide biphenomycin B (1b), a compound exhibiting a potent antibacterial activity against Gram-positive bacteria, is described. The non-proteinogenic amino acid (S,S)-diisotyrosine (2) was prepared by enantioselective hydrogenation of the corresponding didehydroamino acids. The 15-membered ansa ring was obtained in 85% yield within 5 minutes by ring closure of the appropriate linear pentafluorophenyl ester in the two phase system chloroform-aqueous sodium hydrogen carbonate without dilution.